Peripheral nerve blockade and neonatal limb ischemia: Our experience and literature review

Maria Pia De Carolis, Iliana Bersani, Fiammetta Piersigilli, Serena Antonia Rubortone, Federica Occhipinti, Serafina Lacerenza, Costantino Romagnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Considering the high frequency of bleeding complications following fibrinolytic treatment in neonates, peripheral nerve blockade (PNB) has been proposed alone or in association with lower doses of tissue plasminogen activator, as a possible new therapeutic approach in the management of neonatal limb ischemia (LI) secondary to vasospasm and/or thrombosis. The present article provides a review of the current knowledge about the topic, in order to evaluate the efficacy and safety of this therapeutic approach. According to the few case reports documented in literature and to our experience, PNB could be considered as valid procedure for the treatment of LI, especially during neonatal period, when the risk of serious bleeding associated with fibrinolytic or anticoagulant therapy is higher. Peripheral nerve blockade resulted in a safe and effective procedure for the treatment of neonatal vascular spasm and thrombosis.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalClinical and Applied Thrombosis/Hemostasis
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • anticoagulants
  • neonatal thrombosis
  • thrombolytics

ASJC Scopus subject areas

  • Hematology

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