Peripheral nerve involvement in Churg-Strauss syndrome

Raffaella Marazzi, Davide Pareyson, Amerigo Boiardi, Massimo Corbo, Vidmer Scaioli, Angelo Sghirlanzoni

Research output: Contribution to journalArticlepeer-review


Peripheral neuropathy associated with bronchial asthma, multisystem organ dysfunction and idiopathic hypereosinophilia may be found in Churg-Strauss syndrome, hypereosinophilic syndrome and polyarteritis nodosa. Some authors have diagnosed their patients according to the presence in tissue biopsies of the three histological criteria of Churg and Strauss (necrotizing vasculitis, tissue eosinophilic infiltration, extravascular granulomas). We have observed three patients with a common history of a prodromal phase of allergic diseases (bronchial asthma and rhinitis) followed by a vasculitic phase with mononeuritis multiplex, purpura and arthritis, associated with hypereosinophilia of more than 1500 cells/mm3. All responded well to steroid treatment. Sural nerve biopsy revealed true vasculitis in two of these cases and a mild perivascular inflammatory infiltration in the other. On the basis of their characteristic clinical pattern, we think that our cases best fit the diagnosis of Churg-Strauss syndrome even though the typical histological features were not found in the sural nerves examined.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalJournal of Neurology
Issue number6
Publication statusPublished - Jun 1992


  • Allergic granulomatous angiitis
  • Churg-Strauss syndrome
  • Hypereosinophilia
  • Peripheral neuropathy
  • Vasculitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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