Abstract
Peripheral neuropathy associated with bronchial asthma, multisystem organ dysfunction and idiopathic hypereosinophilia may be found in Churg-Strauss syndrome, hypereosinophilic syndrome and polyarteritis nodosa. Some authors have diagnosed their patients according to the presence in tissue biopsies of the three histological criteria of Churg and Strauss (necrotizing vasculitis, tissue eosinophilic infiltration, extravascular granulomas). We have observed three patients with a common history of a prodromal phase of allergic diseases (bronchial asthma and rhinitis) followed by a vasculitic phase with mononeuritis multiplex, purpura and arthritis, associated with hypereosinophilia of more than 1500 cells/mm3. All responded well to steroid treatment. Sural nerve biopsy revealed true vasculitis in two of these cases and a mild perivascular inflammatory infiltration in the other. On the basis of their characteristic clinical pattern, we think that our cases best fit the diagnosis of Churg-Strauss syndrome even though the typical histological features were not found in the sural nerves examined.
| Original language | English |
|---|---|
| Pages (from-to) | 317-321 |
| Number of pages | 5 |
| Journal | Journal of Neurology |
| Volume | 239 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1992 |
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Keywords
- Allergic granulomatous angiitis
- Churg-Strauss syndrome
- Hypereosinophilia
- Peripheral neuropathy
- Vasculitis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Peripheral nerve involvement in Churg-Strauss syndrome. / Marazzi, Raffaella; Pareyson, Davide; Boiardi, Amerigo; Corbo, Massimo; Scaioli, Vidmer; Sghirlanzoni, Angelo.
In: Journal of Neurology, Vol. 239, No. 6, 06.1992, p. 317-321.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral nerve involvement in Churg-Strauss syndrome
AU - Marazzi, Raffaella
AU - Pareyson, Davide
AU - Boiardi, Amerigo
AU - Corbo, Massimo
AU - Scaioli, Vidmer
AU - Sghirlanzoni, Angelo
PY - 1992/6
Y1 - 1992/6
N2 - Peripheral neuropathy associated with bronchial asthma, multisystem organ dysfunction and idiopathic hypereosinophilia may be found in Churg-Strauss syndrome, hypereosinophilic syndrome and polyarteritis nodosa. Some authors have diagnosed their patients according to the presence in tissue biopsies of the three histological criteria of Churg and Strauss (necrotizing vasculitis, tissue eosinophilic infiltration, extravascular granulomas). We have observed three patients with a common history of a prodromal phase of allergic diseases (bronchial asthma and rhinitis) followed by a vasculitic phase with mononeuritis multiplex, purpura and arthritis, associated with hypereosinophilia of more than 1500 cells/mm3. All responded well to steroid treatment. Sural nerve biopsy revealed true vasculitis in two of these cases and a mild perivascular inflammatory infiltration in the other. On the basis of their characteristic clinical pattern, we think that our cases best fit the diagnosis of Churg-Strauss syndrome even though the typical histological features were not found in the sural nerves examined.
AB - Peripheral neuropathy associated with bronchial asthma, multisystem organ dysfunction and idiopathic hypereosinophilia may be found in Churg-Strauss syndrome, hypereosinophilic syndrome and polyarteritis nodosa. Some authors have diagnosed their patients according to the presence in tissue biopsies of the three histological criteria of Churg and Strauss (necrotizing vasculitis, tissue eosinophilic infiltration, extravascular granulomas). We have observed three patients with a common history of a prodromal phase of allergic diseases (bronchial asthma and rhinitis) followed by a vasculitic phase with mononeuritis multiplex, purpura and arthritis, associated with hypereosinophilia of more than 1500 cells/mm3. All responded well to steroid treatment. Sural nerve biopsy revealed true vasculitis in two of these cases and a mild perivascular inflammatory infiltration in the other. On the basis of their characteristic clinical pattern, we think that our cases best fit the diagnosis of Churg-Strauss syndrome even though the typical histological features were not found in the sural nerves examined.
KW - Allergic granulomatous angiitis
KW - Churg-Strauss syndrome
KW - Hypereosinophilia
KW - Peripheral neuropathy
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=0026732572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026732572&partnerID=8YFLogxK
U2 - 10.1007/BF00867587
DO - 10.1007/BF00867587
M3 - Article
C2 - 1324984
AN - SCOPUS:0026732572
VL - 239
SP - 317
EP - 321
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 6
ER -