Peripheral nerve reconstruction with bioabsorbable polyphosphazene conduits

N. Nicoli Aldini, M. Fini, M. Rocca, L. Martini, R. Giardino, P. Caliceti, F. M. Veronese, S. Lora, M. C. Maltarello

Research output: Contribution to journalArticlepeer-review

Abstract

Tubes of poly[bis(ethylalanato)phosphazene], obtained by evaporating the polymer around a 1.3mm diameter capillary, were evaluated as guides for nerve regeneration in an experimental animal model. In six Wistar rats, under general anesthesia and with microsurgical technique, the ischiatic nerve was bilaterally isolated. On the right side, a segment was removed to create a defect of 10mm, that was repaired with the conduit; on the left side the defect was repaired with harvested nerve segment from the right side. Controls at 30, 90, 180 days showed slow and gradual absorption of the conduit without signs of local or general toxicity. Nerve fiber regeneration in the conduits was not significantly different from that obtained with autologous grafts. Polyphosphazene conduits may be considered effective as a guide for nerve regeneration mainly in the perspective of using the polymer matrix as a carrier for neurite-promoting factors.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume12
Issue number1
Publication statusPublished - Jan 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

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