Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Raffaello Nemni, Raffaella Fazio, Massimo Corbo, Carlo Sacchi, Salvatore Smirne, Nicholas Canal

Research output: Contribution to journalArticle

Abstract

In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalJournal of the Neurological Sciences
Volume77
Issue number2-3
DOIs
Publication statusPublished - 1987

Fingerprint

Experimental Neoplasms
Plasma Cell Neoplasms
Peripheral Nervous System Diseases
Paraproteins
Immunoglobulin Light Chains
Mineral Oil
Sciatic Nerve
Peripheral Nerves
Immunoglobulins
Theoretical Models
Neoplasms

Keywords

  • Experimental neuropathy
  • Monoclonal gammopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. / Nemni, Raffaello; Fazio, Raffaella; Corbo, Massimo; Sacchi, Carlo; Smirne, Salvatore; Canal, Nicholas.

In: Journal of the Neurological Sciences, Vol. 77, No. 2-3, 1987, p. 321-329.

Research output: Contribution to journalArticle

Nemni, Raffaello ; Fazio, Raffaella ; Corbo, Massimo ; Sacchi, Carlo ; Smirne, Salvatore ; Canal, Nicholas. / Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse. In: Journal of the Neurological Sciences. 1987 ; Vol. 77, No. 2-3. pp. 321-329.
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