Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Raffaello Nemni, Raffaella Fazio, Massimo Corbo, Carlo Sacchi, Salvatore Smirne, Nicholas Canal

Research output: Contribution to journalArticle

Abstract

In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalJournal of the Neurological Sciences
Volume77
Issue number2-3
DOIs
Publication statusPublished - 1987

Keywords

  • Experimental neuropathy
  • Monoclonal gammopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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