Peripheral neuropathy caused by antiepileptic drugs. Neurophysiological study of the A δ and C fibers

S. Baldini, L. Carenini, M. Leone, G. D'Alessandro, E. Bottacchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The risk that antiepileptic drugs may cause damage to the peripheral nervous system led us to investigate 12 patients on carbamazepine and 12 patients on phenobarbital with the thermal threshold test. The heat and cold thresholds were measured at the ankle and wrist and, compared with those in 30 healthy subjects, they proved to be significantly higher. When the two groups of epileptics were compared separately with the controls, their thresholds were always higher. These findings are consistent with a toxic effect of both drugs on fine peripheral nerve fibers.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume13
Issue number3
DOIs
Publication statusPublished - Apr 1992

Fingerprint

Myelinated Nerve Fibers
Unmyelinated Nerve Fibers
Peripheral Nervous System Diseases
Anticonvulsants
Hot Temperature
Poisons
Carbamazepine
Peripheral Nervous System
Phenobarbital
Wrist
Peripheral Nerves
Nerve Fibers
Ankle
Healthy Volunteers
Pharmaceutical Preparations

Keywords

  • A δ and C fibers
  • Antiepileptic drugs
  • peripheral neuropathy
  • thermal threshold test

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Peripheral neuropathy caused by antiepileptic drugs. Neurophysiological study of the A δ and C fibers. / Baldini, S.; Carenini, L.; Leone, M.; D'Alessandro, G.; Bottacchi, E.

In: Italian Journal of Neurological Sciences, Vol. 13, No. 3, 04.1992, p. 233-238.

Research output: Contribution to journalArticle

Baldini, S. ; Carenini, L. ; Leone, M. ; D'Alessandro, G. ; Bottacchi, E. / Peripheral neuropathy caused by antiepileptic drugs. Neurophysiological study of the A δ and C fibers. In: Italian Journal of Neurological Sciences. 1992 ; Vol. 13, No. 3. pp. 233-238.
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