Peripheral neuropathy in mixed cryoglobulinaemia: clinical assessment and therapeutic approach

Italian Group for the Study of Cryoglobulinaemia (GISC)

Research output: Contribution to journalReview articlepeer-review


Peripheral neuropathy (PN) has been detected in up to 69% of patients with mixed cryoglobulinaemic syndrome (MCS). PN should be considered in any patient with sensory and/or motor signs and symptoms in the limbs. Electrodiagnostic tests are mandatory for the diagnosis of PN. Several different sets of diagnostic criteria have been created to assess it. All patients suspected of having neuropathy should undergo a nerve conduction study. A complete neurological evaluation at baseline and periodically should be done possibly by the same neurologists. The authors recommend rigorous scientific evidences that may help to obtain superior tools for accurate diagnosis and management of these conditions. Clinicians, armed with experience and recommendations, can find in this review data-driven guidelines to apply treatments of MCS and closely related disorders.

Original languageEnglish
Pages (from-to)1231-1237
Number of pages7
JournalClinical and Experimental Rheumatology
Issue number6
Publication statusPublished - Nov 1 2020

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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