Abstract
Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensorymotor neuropathy and PSS. In both, the sural nerve biospsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 63-67 |
| Number of pages | 5 |
| Journal | Clinical Neuropathology |
| Volume | 12 |
| Issue number | 2 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Neuroscience(all)
Cite this
Peripheral neuropathy in scleroderma. / Corbo, M.; Nemni, R.; Iannaccone, S.; Quattrini, A.; Lodi, M.; Praderio, L.; Comola, M.; Lorenzetti, I.; Comi, G.; Canal, N.
In: Clinical Neuropathology, Vol. 12, No. 2, 1993, p. 63-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral neuropathy in scleroderma
AU - Corbo, M.
AU - Nemni, R.
AU - Iannaccone, S.
AU - Quattrini, A.
AU - Lodi, M.
AU - Praderio, L.
AU - Comola, M.
AU - Lorenzetti, I.
AU - Comi, G.
AU - Canal, N.
PY - 1993
Y1 - 1993
N2 - Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensorymotor neuropathy and PSS. In both, the sural nerve biospsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.
AB - Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensorymotor neuropathy and PSS. In both, the sural nerve biospsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027253155&partnerID=8YFLogxK
M3 - Article
C2 - 8386601
AN - SCOPUS:0027253155
VL - 12
SP - 63
EP - 67
JO - Clinical Neuropathology
JF - Clinical Neuropathology
SN - 0722-5091
IS - 2
ER -