Peripheral neuropathy in scleroderma

M. Corbo, R. Nemni, S. Iannaccone, A. Quattrini, M. Lodi, L. Praderio, M. Comola, I. Lorenzetti, G. Comi, N. Canal

Research output: Contribution to journalArticle

Abstract

Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensorymotor neuropathy and PSS. In both, the sural nerve biospsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalClinical Neuropathology
Volume12
Issue number2
Publication statusPublished - 1993

Fingerprint

Diffuse Scleroderma
Peripheral Nervous System Diseases
Peripheral Nerves
Connective Tissue
Sural Nerve
Collagen Type I
Nervous System
Regeneration
Collagen
Western Blotting
Serum
Proteins

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Corbo, M., Nemni, R., Iannaccone, S., Quattrini, A., Lodi, M., Praderio, L., ... Canal, N. (1993). Peripheral neuropathy in scleroderma. Clinical Neuropathology, 12(2), 63-67.

Peripheral neuropathy in scleroderma. / Corbo, M.; Nemni, R.; Iannaccone, S.; Quattrini, A.; Lodi, M.; Praderio, L.; Comola, M.; Lorenzetti, I.; Comi, G.; Canal, N.

In: Clinical Neuropathology, Vol. 12, No. 2, 1993, p. 63-67.

Research output: Contribution to journalArticle

Corbo, M, Nemni, R, Iannaccone, S, Quattrini, A, Lodi, M, Praderio, L, Comola, M, Lorenzetti, I, Comi, G & Canal, N 1993, 'Peripheral neuropathy in scleroderma', Clinical Neuropathology, vol. 12, no. 2, pp. 63-67.
Corbo M, Nemni R, Iannaccone S, Quattrini A, Lodi M, Praderio L et al. Peripheral neuropathy in scleroderma. Clinical Neuropathology. 1993;12(2):63-67.
Corbo, M. ; Nemni, R. ; Iannaccone, S. ; Quattrini, A. ; Lodi, M. ; Praderio, L. ; Comola, M. ; Lorenzetti, I. ; Comi, G. ; Canal, N. / Peripheral neuropathy in scleroderma. In: Clinical Neuropathology. 1993 ; Vol. 12, No. 2. pp. 63-67.
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AU - Iannaccone, S.

AU - Quattrini, A.

AU - Lodi, M.

AU - Praderio, L.

AU - Comola, M.

AU - Lorenzetti, I.

AU - Comi, G.

AU - Canal, N.

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