Peripheral neurotoxicity of taxol in patients previously treated with cisplatin

G. Cavaletti, G. Bogliun, L. Marzorati, A. Zincone, M. Marzola, N. Colombo, G. Tredici

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Taxol is a new anticancer drug that acts as a tubulin polymeration enhancer. Its major toxicities are myelosuppression, hypersensitivity, and mucositis, but it also induces peripheral nerve damage. The use of taxol has recently been proposed for platinum-resistant cancers, but in these cases there is a possibility of cumulative toxicity in the peripheral nervous system. Methods. Twenty-two patients affected by a relapse of cisplatin-treated ovarian cancer were examined clinically and neurophysiologically to determine the evolution of taxol-induced peripheral somatic and autonomic neurotoxicity and the possible cumulative effect of a combination of taxol and cisplatin. Each patient was examined before, during, and after taxol treatment (using a dose of 135 or 175 mg/m2 in 3 hours every 3 weeks). Results. No patients were excluded from the study because of unacceptable toxicities of any kind. The serial examinations demonstrated that taxol induced onset of (or worsening of preexisting) neuropathic symptoms and signs in almost all the patients. The features were those of a distal, symmetrical, sensory polyneuropathy due to an axonopathy. Motor nerves and the autonomic nervous system were unaffected. Taxol neurotoxicity appeared early in the course of the treatment (i.e., after three courses) and was not severely disabling. In most cases after the early onset of peripheral neuropathy, stabilization of this side effect occurred. Conclusions. Considering the low doses of taxol used in this study, the sensory nerve damage was unexpectedly severe. It appears that a cumulative, but not dose- limiting, neurotoxic effect occurs using taxol in patients previously treated with cisplatin.

Original languageEnglish
Pages (from-to)1141-1150
Number of pages10
JournalCancer
Volume75
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • chemotherapy
  • cisplatin
  • neurophysiology
  • ovarian cancer
  • peripheral neuropathy
  • taxol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Peripheral neurotoxicity of taxol in patients previously treated with cisplatin'. Together they form a unique fingerprint.

Cite this