Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury

Roberto Aquilani, Simona Viglio, Paolo Iadarola, Caterina Guarnaschelli, Nadia Arrigoni, Gloria Fugazza, Mariana Catapano, Federica Boschi, Maurizia Dossena, Ornella Pastoris

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Acute severe brain injury causes an increased mobilization of amino acids from tissue. The plasma amino acid profile of patients undergoing rehabilitation after brain injury is unknown. This study was aimed at delineating the plasma amino acid profile of rehabilitation patients with brain injury. Design: Peripheral plasma aminogram, lactate, pyruvate, glycerol, ketone body, and carnitine concentrations were determined in 11 patients with brain injury (34.6 ± 15 years old, 60 ± 16.8 days after injury) and in 8 controls. Resting energy expenditure and nitrogen balance were also determined. Results: (1) All essential amino acids and about 50% of nonessential amino acids were significantly lower in brain injury patients than in controls (p <.05). (2) Plasma amino acids were lower irrespective of either energy and protein intake or nitrogen balance. (3) Total carnitine concentration and esterified/free carnitine ratio were higher in brain injury patients than in controls (p <.05). Conclusions: Rehabilitation patients with brain injury may have an important reduction of their plasma aminogram. Muscle tissue depletion and the persistence of a hypercatabolic state caused by subclinical infections, pressure sores, and immobility may contribute to this reduction. (C) 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Volume81
Issue number2
DOIs
Publication statusPublished - Feb 2000

Fingerprint

Brain Injuries
Rehabilitation
Amino Acids
Carnitine
Nitrogen
Ketone Bodies
Asymptomatic Infections
Essential Amino Acids
Pressure Ulcer
Energy Intake
Pyruvic Acid
Glycerol
Energy Metabolism
Lactic Acid
Muscles
Wounds and Injuries
Proteins

Keywords

  • Amino acids
  • Brain injury
  • Plasma
  • Rehabilitation

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Aquilani, R., Viglio, S., Iadarola, P., Guarnaschelli, C., Arrigoni, N., Fugazza, G., ... Pastoris, O. (2000). Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury. Archives of Physical Medicine and Rehabilitation, 81(2), 176-181. https://doi.org/10.1053/apmr.2000.0810176

Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury. / Aquilani, Roberto; Viglio, Simona; Iadarola, Paolo; Guarnaschelli, Caterina; Arrigoni, Nadia; Fugazza, Gloria; Catapano, Mariana; Boschi, Federica; Dossena, Maurizia; Pastoris, Ornella.

In: Archives of Physical Medicine and Rehabilitation, Vol. 81, No. 2, 02.2000, p. 176-181.

Research output: Contribution to journalArticle

Aquilani, R, Viglio, S, Iadarola, P, Guarnaschelli, C, Arrigoni, N, Fugazza, G, Catapano, M, Boschi, F, Dossena, M & Pastoris, O 2000, 'Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury', Archives of Physical Medicine and Rehabilitation, vol. 81, no. 2, pp. 176-181. https://doi.org/10.1053/apmr.2000.0810176
Aquilani, Roberto ; Viglio, Simona ; Iadarola, Paolo ; Guarnaschelli, Caterina ; Arrigoni, Nadia ; Fugazza, Gloria ; Catapano, Mariana ; Boschi, Federica ; Dossena, Maurizia ; Pastoris, Ornella. / Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury. In: Archives of Physical Medicine and Rehabilitation. 2000 ; Vol. 81, No. 2. pp. 176-181.
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