Peripheral primitive neuroectodermal tumour of the cervix

P. Pauwels, P. Ambros, C. Hattinger, M. Lammens, P. Dal Cin, J. Ribot, A. Struyk, H. Van Den Berghe

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral primitive neuro-ectodermal tumours (PNET) of the cervix are very rare. Here, we report the clinical, pathological, immunohistochemical and genetic features of a case of a PNET located in the cervix. Hysterectomy revealed a cervical tumour. On microscopic examination, a vaguely lobular arrangement of uniformly appearing neoplastic cells, with round to oval nuclei, distinct nuclear membranes and a clear, moderately glycogen-rich cytoplasm was seen. Cells stained positive for LEU 7, S 100, monoclonal NSE and particularly for MIC2. Neurogenic differentiation was also seen by electron microscopic examination. The genetic hallmark of PNET, a 22q12 rearrangement was demonstrated by fluorescence in situ hybridisation experiments, supporting the diagnosis. Awareness of the existence of primary PNET of the cervix is important to avoid confusion with other tumours of the cervix.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalVirchows Archiv
Volume436
Issue number1
Publication statusPublished - 2000

Keywords

  • Cervix
  • Cytogenetics
  • Immunohistochemistry
  • Peripheral primitive neuroectodermal tumour Ewing's tumour pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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