Peripheral T-cell lymphoma classification: The matter of cellular derivation

Pier Paolo Piccaluga, Claudio Agostinelli, Claudio Tripodo, Anna Gazzola, Francesco Bacci, Elena Sabattini, Stefano A. Pileri

Research output: Contribution to journalArticle

Abstract

Peripheral T-cell lymphomas (PTCLs) represent approximately 12% of all non-Hodgkin's lymphomas in Western countries. They are quite heterogeneous as far as morphology and phenotype are concerned. Furthermore, until now, PTCLs could not be referred to specific normal counterparts, in contrast to B-cell-derived non-Hodgkin's lymphomas. In particular, in the last edition of the WHO classification of Tumors of the Hematopoietic and Lymphoid Tissues, for the majority of nodal PTCLs (including the not otherwise specified type and anaplastic large-cell lymphoma), the postulated cell of origin remained undefined. However, in the last few years, high-throughput genomic techniques, especially gene-expression profiling, have allowed us to better define the relationship between some entities and the different T-cell subpopulations. Consequently, it has become possible to clearly define, for example, the association between angioimmunoblastic T-cell lymphoma and T-follicular helper cells. In addition, within PTCLs/not otherwise specified, different subgroups were identified based on their similarity to different cellular counterparts, including T-helper, T-cytotoxic and T-follicular helper cells. In this article, based on their own experience as well as up-to-date literature, the authors revise the concept of PTCL classification by specially focusing on their cellular counterparts and discuss the possible clinical relevance of such an approach.

Original languageEnglish
Pages (from-to)415-425
Number of pages11
JournalExpert Review of Hematology
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Peripheral T-Cell Lymphoma
Helper-Inducer T-Lymphocytes
Non-Hodgkin's Lymphoma
Anaplastic Large-Cell Lymphoma
T-Cell Lymphoma
Gene Expression Profiling
Lymphoid Tissue
B-Lymphocytes
T-Lymphocytes
Phenotype
Neoplasms

Keywords

  • cytotoxic
  • gene-expression profile
  • peripheral T-cell lymphomas
  • T lymphocytes
  • Tfh

ASJC Scopus subject areas

  • Hematology

Cite this

Piccaluga, P. P., Agostinelli, C., Tripodo, C., Gazzola, A., Bacci, F., Sabattini, E., & Pileri, S. A. (2011). Peripheral T-cell lymphoma classification: The matter of cellular derivation. Expert Review of Hematology, 4(4), 415-425. https://doi.org/10.1586/ehm.11.37

Peripheral T-cell lymphoma classification : The matter of cellular derivation. / Piccaluga, Pier Paolo; Agostinelli, Claudio; Tripodo, Claudio; Gazzola, Anna; Bacci, Francesco; Sabattini, Elena; Pileri, Stefano A.

In: Expert Review of Hematology, Vol. 4, No. 4, 08.2011, p. 415-425.

Research output: Contribution to journalArticle

Piccaluga, PP, Agostinelli, C, Tripodo, C, Gazzola, A, Bacci, F, Sabattini, E & Pileri, SA 2011, 'Peripheral T-cell lymphoma classification: The matter of cellular derivation', Expert Review of Hematology, vol. 4, no. 4, pp. 415-425. https://doi.org/10.1586/ehm.11.37
Piccaluga PP, Agostinelli C, Tripodo C, Gazzola A, Bacci F, Sabattini E et al. Peripheral T-cell lymphoma classification: The matter of cellular derivation. Expert Review of Hematology. 2011 Aug;4(4):415-425. https://doi.org/10.1586/ehm.11.37
Piccaluga, Pier Paolo ; Agostinelli, Claudio ; Tripodo, Claudio ; Gazzola, Anna ; Bacci, Francesco ; Sabattini, Elena ; Pileri, Stefano A. / Peripheral T-cell lymphoma classification : The matter of cellular derivation. In: Expert Review of Hematology. 2011 ; Vol. 4, No. 4. pp. 415-425.
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