Peripheral T-cell lymphoma unspecified (PTCL-U): A new prognostic model from a retrospective multicentric clinical study

Andrea Gallamini, Caterina Stelitano, Roberta Calvi, Monica Bellei, Daniele Mattei, Umberto Vitolo, Fortunato Morabito, Maurizio Martelli, Ercole Brusamolino, Emilio Iannitto, Francesco Zaja, Sergio Cortelazzo, Luigi Rigacci, Liliana Devizzi, Giuseppe Todeschini, Gino Santini, Maura Brugiatelli, Massimo Federico

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the prognosis of peripheral T-cell lymphoma unspecified, we retrospectively analyzed 385 cases fulfilling the criteria defined by the World Health Organization classification. Factors associated with a worse overall survival (OS) in a univariate analysis were age older than 60 years (P= .0002), equal to or more than 2 extranodal sites (P = .0002), lactic dehydrogenase (LDH) value at normal levels or above (P <.0001), performance status (PS) equal to or more than 2 (P≤.0001), stage III or higher (P = .0001), and bone marrow involvement (P = .0001). Multivariate anelysis analysis showed that age (relative risk, 1.732; 95% Cl, 1.300-2.309; P <.0001), PS (relative risk, 1.719; 95% Cl, 1.269-2.327, P <.0001), LDH level (relative risk, 1.905; 95% Cl, 1.415-2.564; P <.0001), and bone marrow Involvement (relative risk, 1.454; 95% Cl, 1.045-2.023; P = .026) were factors independently predictive for survival. Using these 4 variables we constructed a new prognostic model that singled out 4 groups at different risk: group 1, no adverse factors, with 5-year and 10-year OS of 62.3% and 54.9%, respectively; group 2, one factor, with a 5-year and 10-year OS of 52.9% and 38.8%, respectively; group 3, 2 factors, with 5-year and 10-year OS of 32.9% and 18.0%, respectively; group 4, 3 or 4 factors, with a 5-year and 10-yrer OS of 18.3 and 12.6%, respectively; (P ≤ .0001; log-rank, 66.79).

Original languageEnglish
Pages (from-to)2474-2479
Number of pages6
JournalBlood
Volume103
Issue number7
DOIs
Publication statusPublished - Apr 1 2004

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Peripheral T-cell lymphoma unspecified (PTCL-U): A new prognostic model from a retrospective multicentric clinical study'. Together they form a unique fingerprint.

Cite this