Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

Gabriella Aquino, Renato Franco, Fioravante Ronconi, Annamaria Anniciello, Luigi Russo, Annarosaria De Chiara, Luigi Panico

Research output: Contribution to journalArticlepeer-review


Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.Virtual slide: The virtual slides for this article can be found here:

Original languageEnglish
Article number79
JournalDiagnostic Pathology
Issue number1
Publication statusPublished - Jul 6 2012


  • CCND1 copy gain
  • Cyclin D1 over-expression
  • FISH
  • Peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine


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