Peripheral TH-17 cells in children with allergic rhinitis: Preliminary report

Giorgio Ciprandi, A. M. Castellazzi, D. Fenoglio, F. Battaglia, G. Marseglia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Th17 is a subset of T helper lymphocytes and exerts pro-inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in the most severe patients with birch allergy studied both outside and during the pollen season. This study aims to compare the frequency of peripheral IL-17-producing T cells in children with allergic rhinitis and in healthy controls. Ten children with allergic rhinitis and 5 healthy non-allergic subjects were evaluated. Th17 were evaluated by intracellular staining in ex-vivo T cell compartment. Ex- vivo PBMNC evaluation showed that allergic patients had higher frequencies of IL-17 producing T cells, both concerning CD4+ and CD8+ cells. In particular, there is a subset co-expressing IL-17 and IFN-γ both for CD4+ and CD8+ cells. In conclusion, this preliminary study suggests a possible role of Th-17 cells in the response to allergens in children.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalInternational Journal of Immunopathology and Pharmacology
Volume23
Issue number1
Publication statusPublished - Jan 2010

Fingerprint

Th17 Cells
Interleukin-17
T-Lymphocytes
Betula
Helper-Inducer T-Lymphocytes
Pollen
Allergens
Hypersensitivity
Staining and Labeling
Allergic Rhinitis
Serum

Keywords

  • Allergic rhinitis
  • CD4+ and CD8+ cells
  • Children
  • Th-17 cells

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

Peripheral TH-17 cells in children with allergic rhinitis : Preliminary report. / Ciprandi, Giorgio; Castellazzi, A. M.; Fenoglio, D.; Battaglia, F.; Marseglia, G.

In: International Journal of Immunopathology and Pharmacology, Vol. 23, No. 1, 01.2010, p. 379-382.

Research output: Contribution to journalArticle

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