Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases: Effects of end-stage renal disease and microinflammatory state

G. Garibotto, A. Sofia, V. Procopio, B. Villaggio, A. Tarroni, M. Di Martino, V. Cappelli, M. T. Gandolfo, F. Aloisi, F. De Cian, M. R. Sala, D. Verzola

Research output: Contribution to journalArticle

Abstract

To examine if uremia influences muscle interleukin-6 (IL-6) metabolism we studied the exchange of IL-6 across the forearm in 16 patients with chronic kidney disease (CKD) (stages 3 and 4), in 15 hemodialysis (HD)-treated end-stage renal disease (ESRD) patients (n = 15), and in six healthy controls. In addition, we performed an analysis of both IL-6 protein and IL-6 mRNA expression in muscle of CKD (stage 4) patients showing evidence of inflammation and in controls. A release of IL-6 from the forearm was observed in patients with elevated IL-6 plasma levels. Arterial IL-6 was directly related to released IL-6 (r = 0.69; P

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalKidney International
Volume70
Issue number2
DOIs
Publication statusPublished - Jul 7 2006

Keywords

  • Inflammation
  • Interleukin-6
  • Skeletal muscle
  • Uremia

ASJC Scopus subject areas

  • Nephrology

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    Garibotto, G., Sofia, A., Procopio, V., Villaggio, B., Tarroni, A., Di Martino, M., Cappelli, V., Gandolfo, M. T., Aloisi, F., De Cian, F., Sala, M. R., & Verzola, D. (2006). Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases: Effects of end-stage renal disease and microinflammatory state. Kidney International, 70(2), 384-390. https://doi.org/10.1038/sj.ki.5001570