Peripheral T/NK-cell lymphoma: A report of the IXth workshop of the European Association for Haematopathology

P. M. Kluin, A. Feller, P. Gaulard, E. S. Jaffe, C. J L M Meijer, H. K. Müller-Hermelink, S. Pileri

Research output: Contribution to journalArticle

Abstract

Aims: In April 1998, The European Association for Haematopathology organized the IXth workshop on peripheral T-cell and NK-cell lymphomas and leukaemias. The workshop focused on unusual subtypes of these rare malignancies, allowing evaluation of the recently published WHO classification of neoplastic diseases of the lymphoid tissues. Methods and results: One-hundred and three cases were centrally immunophenotyped and hybridized for EBER1/2 of Epstein-Barr virus. All cases were reviewed by a panel of experienced haematopathologists and classified according to the new WHO classification for lymphoid neoplasms. Three cases were considered as precursor T-cell and 95 cases as peripheral T/NK-cell lymphoma/leukaemia. Although the cases represented a selected series of unusual cases, the following conclusions could be made: (i) Most lymphomas except the hepatosplenic γ/δ T-cell lymphomas showed a rather broad morphological spectrum, with differences both between and within individual tumours. (ii) This heterogeneity was also reflected by the immunophenotype, for instance a variable expression of CD30 was found in many enteropathy type T-cell lymphomas. (iii) Exceptions in phenotype were regularly found in almost all categories, indicating that phenotype should not be the final determining factor in classification. (iv) The great majority of T-cell lymphomas expressed the α/β T-cell receptor, with the exception of all but one hepatosplenic T-cell lymphomas and a few other extranodal peripheral T cell lymphomas. (v) Malignancies of precursor cells, blastic NK-cell lymphoma/leukaemia, adult T-cell lymphoma/leukaemia and most AIL-type T-cell lymphomas did not express cytotoxic molecules such as TIA1 and granzyme-B. In contrast, all five aggressive NK/T-cell lymphomas/leukaemias, a single case of large granular lymphocyte leukaemia and 40 of 47 primary extranodal lymphoma/leukaemias expressed these molecules. In hepatosplenic γ/δ T-cell lymphoma, five of six cases showed expression of TIA1 but not of granzyme-B. (vi) Seven tumours developed after organ-transplant, four cases being EBV-positive. No distinct phenotype could be attributed to these cases. Conclusions: Most peripheral T/NK cell lymphomas could be categorized as distinct entities as described in the recently proposed WHO classification for lymphoid neoplasms.

Original languageEnglish
Pages (from-to)250-270
Number of pages21
JournalHistopathology
Volume38
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Peripheral T-Cell Lymphoma
T-Cell Lymphoma
Natural Killer Cells
Education
Lymphoma
Leukemia
Granzymes
Neoplasms
Human Herpesvirus 4
Phenotype
Large Granular Lymphocytic Leukemia
T-Lymphoid Precursor Cells
T-Cell Leukemia
Adult T Cell Leukemia Lymphoma
Lymphoid Tissue
T-Cell Antigen Receptor
T-Lymphocytes
Transplants

Keywords

  • Classification
  • Epstein-Barr virus
  • NK cell
  • Non-Hodgkin's lymphoma
  • Pathology
  • T cell

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Kluin, P. M., Feller, A., Gaulard, P., Jaffe, E. S., Meijer, C. J. L. M., Müller-Hermelink, H. K., & Pileri, S. (2001). Peripheral T/NK-cell lymphoma: A report of the IXth workshop of the European Association for Haematopathology. Histopathology, 38(3), 250-270. https://doi.org/10.1046/j.1365-2559.2001.01058.x

Peripheral T/NK-cell lymphoma : A report of the IXth workshop of the European Association for Haematopathology. / Kluin, P. M.; Feller, A.; Gaulard, P.; Jaffe, E. S.; Meijer, C. J L M; Müller-Hermelink, H. K.; Pileri, S.

In: Histopathology, Vol. 38, No. 3, 2001, p. 250-270.

Research output: Contribution to journalArticle

Kluin, PM, Feller, A, Gaulard, P, Jaffe, ES, Meijer, CJLM, Müller-Hermelink, HK & Pileri, S 2001, 'Peripheral T/NK-cell lymphoma: A report of the IXth workshop of the European Association for Haematopathology', Histopathology, vol. 38, no. 3, pp. 250-270. https://doi.org/10.1046/j.1365-2559.2001.01058.x
Kluin, P. M. ; Feller, A. ; Gaulard, P. ; Jaffe, E. S. ; Meijer, C. J L M ; Müller-Hermelink, H. K. ; Pileri, S. / Peripheral T/NK-cell lymphoma : A report of the IXth workshop of the European Association for Haematopathology. In: Histopathology. 2001 ; Vol. 38, No. 3. pp. 250-270.
@article{6a96f74e54bf495ea0bdd711ed122179,
title = "Peripheral T/NK-cell lymphoma: A report of the IXth workshop of the European Association for Haematopathology",
abstract = "Aims: In April 1998, The European Association for Haematopathology organized the IXth workshop on peripheral T-cell and NK-cell lymphomas and leukaemias. The workshop focused on unusual subtypes of these rare malignancies, allowing evaluation of the recently published WHO classification of neoplastic diseases of the lymphoid tissues. Methods and results: One-hundred and three cases were centrally immunophenotyped and hybridized for EBER1/2 of Epstein-Barr virus. All cases were reviewed by a panel of experienced haematopathologists and classified according to the new WHO classification for lymphoid neoplasms. Three cases were considered as precursor T-cell and 95 cases as peripheral T/NK-cell lymphoma/leukaemia. Although the cases represented a selected series of unusual cases, the following conclusions could be made: (i) Most lymphomas except the hepatosplenic γ/δ T-cell lymphomas showed a rather broad morphological spectrum, with differences both between and within individual tumours. (ii) This heterogeneity was also reflected by the immunophenotype, for instance a variable expression of CD30 was found in many enteropathy type T-cell lymphomas. (iii) Exceptions in phenotype were regularly found in almost all categories, indicating that phenotype should not be the final determining factor in classification. (iv) The great majority of T-cell lymphomas expressed the α/β T-cell receptor, with the exception of all but one hepatosplenic T-cell lymphomas and a few other extranodal peripheral T cell lymphomas. (v) Malignancies of precursor cells, blastic NK-cell lymphoma/leukaemia, adult T-cell lymphoma/leukaemia and most AIL-type T-cell lymphomas did not express cytotoxic molecules such as TIA1 and granzyme-B. In contrast, all five aggressive NK/T-cell lymphomas/leukaemias, a single case of large granular lymphocyte leukaemia and 40 of 47 primary extranodal lymphoma/leukaemias expressed these molecules. In hepatosplenic γ/δ T-cell lymphoma, five of six cases showed expression of TIA1 but not of granzyme-B. (vi) Seven tumours developed after organ-transplant, four cases being EBV-positive. No distinct phenotype could be attributed to these cases. Conclusions: Most peripheral T/NK cell lymphomas could be categorized as distinct entities as described in the recently proposed WHO classification for lymphoid neoplasms.",
keywords = "Classification, Epstein-Barr virus, NK cell, Non-Hodgkin's lymphoma, Pathology, T cell",
author = "Kluin, {P. M.} and A. Feller and P. Gaulard and Jaffe, {E. S.} and Meijer, {C. J L M} and M{\"u}ller-Hermelink, {H. K.} and S. Pileri",
year = "2001",
doi = "10.1046/j.1365-2559.2001.01058.x",
language = "English",
volume = "38",
pages = "250--270",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Peripheral T/NK-cell lymphoma

T2 - A report of the IXth workshop of the European Association for Haematopathology

AU - Kluin, P. M.

AU - Feller, A.

AU - Gaulard, P.

AU - Jaffe, E. S.

AU - Meijer, C. J L M

AU - Müller-Hermelink, H. K.

AU - Pileri, S.

PY - 2001

Y1 - 2001

N2 - Aims: In April 1998, The European Association for Haematopathology organized the IXth workshop on peripheral T-cell and NK-cell lymphomas and leukaemias. The workshop focused on unusual subtypes of these rare malignancies, allowing evaluation of the recently published WHO classification of neoplastic diseases of the lymphoid tissues. Methods and results: One-hundred and three cases were centrally immunophenotyped and hybridized for EBER1/2 of Epstein-Barr virus. All cases were reviewed by a panel of experienced haematopathologists and classified according to the new WHO classification for lymphoid neoplasms. Three cases were considered as precursor T-cell and 95 cases as peripheral T/NK-cell lymphoma/leukaemia. Although the cases represented a selected series of unusual cases, the following conclusions could be made: (i) Most lymphomas except the hepatosplenic γ/δ T-cell lymphomas showed a rather broad morphological spectrum, with differences both between and within individual tumours. (ii) This heterogeneity was also reflected by the immunophenotype, for instance a variable expression of CD30 was found in many enteropathy type T-cell lymphomas. (iii) Exceptions in phenotype were regularly found in almost all categories, indicating that phenotype should not be the final determining factor in classification. (iv) The great majority of T-cell lymphomas expressed the α/β T-cell receptor, with the exception of all but one hepatosplenic T-cell lymphomas and a few other extranodal peripheral T cell lymphomas. (v) Malignancies of precursor cells, blastic NK-cell lymphoma/leukaemia, adult T-cell lymphoma/leukaemia and most AIL-type T-cell lymphomas did not express cytotoxic molecules such as TIA1 and granzyme-B. In contrast, all five aggressive NK/T-cell lymphomas/leukaemias, a single case of large granular lymphocyte leukaemia and 40 of 47 primary extranodal lymphoma/leukaemias expressed these molecules. In hepatosplenic γ/δ T-cell lymphoma, five of six cases showed expression of TIA1 but not of granzyme-B. (vi) Seven tumours developed after organ-transplant, four cases being EBV-positive. No distinct phenotype could be attributed to these cases. Conclusions: Most peripheral T/NK cell lymphomas could be categorized as distinct entities as described in the recently proposed WHO classification for lymphoid neoplasms.

AB - Aims: In April 1998, The European Association for Haematopathology organized the IXth workshop on peripheral T-cell and NK-cell lymphomas and leukaemias. The workshop focused on unusual subtypes of these rare malignancies, allowing evaluation of the recently published WHO classification of neoplastic diseases of the lymphoid tissues. Methods and results: One-hundred and three cases were centrally immunophenotyped and hybridized for EBER1/2 of Epstein-Barr virus. All cases were reviewed by a panel of experienced haematopathologists and classified according to the new WHO classification for lymphoid neoplasms. Three cases were considered as precursor T-cell and 95 cases as peripheral T/NK-cell lymphoma/leukaemia. Although the cases represented a selected series of unusual cases, the following conclusions could be made: (i) Most lymphomas except the hepatosplenic γ/δ T-cell lymphomas showed a rather broad morphological spectrum, with differences both between and within individual tumours. (ii) This heterogeneity was also reflected by the immunophenotype, for instance a variable expression of CD30 was found in many enteropathy type T-cell lymphomas. (iii) Exceptions in phenotype were regularly found in almost all categories, indicating that phenotype should not be the final determining factor in classification. (iv) The great majority of T-cell lymphomas expressed the α/β T-cell receptor, with the exception of all but one hepatosplenic T-cell lymphomas and a few other extranodal peripheral T cell lymphomas. (v) Malignancies of precursor cells, blastic NK-cell lymphoma/leukaemia, adult T-cell lymphoma/leukaemia and most AIL-type T-cell lymphomas did not express cytotoxic molecules such as TIA1 and granzyme-B. In contrast, all five aggressive NK/T-cell lymphomas/leukaemias, a single case of large granular lymphocyte leukaemia and 40 of 47 primary extranodal lymphoma/leukaemias expressed these molecules. In hepatosplenic γ/δ T-cell lymphoma, five of six cases showed expression of TIA1 but not of granzyme-B. (vi) Seven tumours developed after organ-transplant, four cases being EBV-positive. No distinct phenotype could be attributed to these cases. Conclusions: Most peripheral T/NK cell lymphomas could be categorized as distinct entities as described in the recently proposed WHO classification for lymphoid neoplasms.

KW - Classification

KW - Epstein-Barr virus

KW - NK cell

KW - Non-Hodgkin's lymphoma

KW - Pathology

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=0034832379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034832379&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2559.2001.01058.x

DO - 10.1046/j.1365-2559.2001.01058.x

M3 - Article

C2 - 11260307

AN - SCOPUS:0034832379

VL - 38

SP - 250

EP - 270

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 3

ER -