Peripheral vascular resistance limits exercise functional capacity of mild hypertensives

Pietro Amedeo Modesti, Giuseppe Olivo, Francesco Pestelli, Federica Rocchi, Simone Vanni, Renzo Camajori Tedeschini, Ilaria Cecioni, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review


To evaluate the physiological basis for suboptimal peak exercise oxygen consumption (V̇O2p) observed in the early stage of hypertension, 25 WHO Stage I hypertensive men with normal left ventricular mass and 10 healthy control subjects of equivalent age underwent the maximal cardiopulmonary exercise test with contemporary measurement of cardiac output with Tc99m angiocardiography. At peak exercise hypertensive patients had lower V̇O2p (p <0.045) and cardiac output (p <0.014) and higher vascular resistance (p <0.010) than controls. At multiple regression analysis V̇O2 was positively related to cardiac output in controls (r = 0.80, p <0.02), whereas in hypertensives the best (negative) correlation was observed with peripheral vascular resistance (r = -0.72, p <0.04). Thus reduced cardiopulmonary function during physical exercise in hypertensives seems to be mainly related to impaired peripheral vascular autoregulation.

Original languageEnglish
Pages (from-to)473-478
Number of pages6
Issue number6
Publication statusPublished - Jun 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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