To evaluate the physiological basis for suboptimal peak exercise oxygen consumption (V̇O2p) observed in the early stage of hypertension, 25 WHO Stage I hypertensive men with normal left ventricular mass and 10 healthy control subjects of equivalent age underwent the maximal cardiopulmonary exercise test with contemporary measurement of cardiac output with Tc99m angiocardiography. At peak exercise hypertensive patients had lower V̇O2p (p <0.045) and cardiac output (p <0.014) and higher vascular resistance (p <0.010) than controls. At multiple regression analysis V̇O2 was positively related to cardiac output in controls (r = 0.80, p <0.02), whereas in hypertensives the best (negative) correlation was observed with peripheral vascular resistance (r = -0.72, p <0.04). Thus reduced cardiopulmonary function during physical exercise in hypertensives seems to be mainly related to impaired peripheral vascular autoregulation.
|Number of pages||6|
|Publication status||Published - Jun 1999|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine