Periprosthetic osteolysis: a narrative review

A Marmotti, D Messina, A Cykowska, C Beltramo, E Bellato, D Colombero, G Agati, L Mangiavini, M Bruzzone, F Dettoni, G M Peretti, F Castoldi

Research output: Contribution to journalReview articlepeer-review


Periprosthetic osteolysis is still one of the major limitations of prosthetic joints longevity. The process of this "silent" iatrogenic disease involves both mechanical and biological factors that initiate a local immune response in the periprosthetic tissue that eventually lead to implant loosening and failure. There are many causes of the primary aseptic loosening inside the periprosthetic microenvironment, but the most important elements are the wear debris and the cell-particle interactions. Together with implant position, micromotion, bearings, joint fluid pressure, and increased load on the joints drive the pathogenesis of the disease. This narrative review aims to summarise recent studies describing the biological and mechanical factors in the pathogenesis of osteolysis and some of the current pharmacological attempts to "rescue" a failing implant.

Original languageEnglish
Pages (from-to)405-417. Congress of the Italian Orthopaedic Research Society
Number of pages13
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number4 Suppl. 3
Publication statusPublished - Dec 3 2020


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