Perisurgical and intra-rehabilitative salivary steroid hormone profiles in bicompartmental arthroplasty

S. Perego, D. Grasso, B. D. Bodini, F. Cavaiani, C. De Santis, N. Ursino, C. Pelosi, G. Banfi, G. Lombardi

Research output: Contribution to journalArticle

Abstract

Sex hormones play a role in pain perception, a key variable in evaluating the progression and treatment of osteoarthritis. The aim of this study was to determine the relationship between salivary concentrations of four steroid hormones and functional/clinical outcomes after hip and knee arthroplasty. Saliva samples were collected from 24 otherwise healthy patients with osteoarthritis before surgery, on admission to rehabilitation, and at hospital discharge. Salivary concentrations of testosterone, 17β-estradiol, dehydroepiandrosterone (DHEA), and cortisol were immunoassayed. Changes in hormone levels were compared with clinical outcomes, as assessed by functional independence measure (FIM®), Barthel Index (BI), and visual analog scale for pain (VAS) scores. Changes in testosterone levels were significantly inversely correlated with VAS (r= -0.53, p=0.043) and FIM® and BI scores in all patients (r= -0.30, p= 0.043, and r= -0.35, p=0.031, respectively). The testosterone to cortisol ratio was inversely correlated with BI scores in all patients (r= -0.30, p=0.040), and in the men (r= -0.55, p=0.005) and the women (r= -0.28, p=0.042) when analyzed separately. Changes in salivary testosterone concentrations closely correlated with clinical outcome measurements for total hip and knee arthroplasty. Clinical outcome after arthroplasty was generally better among the men.

Original languageEnglish
Pages (from-to)953-960
Number of pages8
JournalJournal of Biological Regulators and Homeostatic Agents
Volume29
Issue number4
Publication statusPublished - Oct 1 2015

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Arthroplasty
Testosterone
Steroids
Hormones
Knee Replacement Arthroplasties
Pain Measurement
Osteoarthritis
Hydrocortisone
Hip
Pain Perception
Dehydroepiandrosterone
Gonadal Steroid Hormones
Saliva
Estradiol
Rehabilitation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perisurgical and intra-rehabilitative salivary steroid hormone profiles in bicompartmental arthroplasty. / Perego, S.; Grasso, D.; Bodini, B. D.; Cavaiani, F.; De Santis, C.; Ursino, N.; Pelosi, C.; Banfi, G.; Lombardi, G.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 29, No. 4, 01.10.2015, p. 953-960.

Research output: Contribution to journalArticle

Perego, S, Grasso, D, Bodini, BD, Cavaiani, F, De Santis, C, Ursino, N, Pelosi, C, Banfi, G & Lombardi, G 2015, 'Perisurgical and intra-rehabilitative salivary steroid hormone profiles in bicompartmental arthroplasty', Journal of Biological Regulators and Homeostatic Agents, vol. 29, no. 4, pp. 953-960.
Perego, S. ; Grasso, D. ; Bodini, B. D. ; Cavaiani, F. ; De Santis, C. ; Ursino, N. ; Pelosi, C. ; Banfi, G. ; Lombardi, G. / Perisurgical and intra-rehabilitative salivary steroid hormone profiles in bicompartmental arthroplasty. In: Journal of Biological Regulators and Homeostatic Agents. 2015 ; Vol. 29, No. 4. pp. 953-960.
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