Peritoneal carcinomatosis: Cytoreductive surgery and HIPEC-overview and basics

Björn L D M Brcher, Pompiliu Piso, Vic Verwaal, Jesus Esquivel, Marcello Derraco, Yutaka Yonemura, Santiago Gonzalez-Moreno, Jörg Pelz, Alfred Königsrainer, Michael Ströhlein, Edward A. Levine, David Morris, David Bartlett, Olivier Glehen, Alfredo Garofalo, Aviram Nissan

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor involvement of the peritoneumperitoneal carcinomatosisis a heterogeneous form of cancer that had been generally regarded as a sign of systemic tumor disease and as a terminal condition. The multimodal treatment approach for patients with peritoneal carcinomatosis, which had been conceived and developed, consists of what is known as cytoreductive surgery, followed by hyperthermic intraperitoneal chemotherapy (HIPEC). Depending on the tumor mass as assessed intraoperatively and the histopathological differentiation, patients who undergo cytoreductive surgery and HIPEC have a significant survival benefit. Mean increases in the survival period ranging from six months to up to four years have now been reported. In view of the substantial logistic effort and the extent of the surgery involved, this treatment approach represents a major challenge both for patients and for surgical oncologists, as well as for the members of the overall interdisciplinary structure required, which includes oncology, anesthesiology and intensive care, psycho-oncology, and patient management. The surgical procedures alone may take 814 hr. The present paper provides an overview of the basis for the approach and the use of specialized classifications and quantitative prognostic indicators.

Original languageEnglish
Pages (from-to)209-224
Number of pages16
JournalCancer Investigation
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Colon cancer
  • Gastric cancer
  • HIPEC
  • Peritoneal carcinomatosis
  • Pseudomyxoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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