Peritoneal carcinomatosis in non-small-cell lung cancer: retrospective multicentric analysis and literature review

Maria Ida Abbate, Diego Luigi Cortinovis, Marcello Tiseo, Tiziana Vavalà, Giulio Cerea, Luca Toschi, Stefania Canova, Francesca Colonese, Paolo Bidoli

Research output: Contribution to journalReview article

Abstract

AIM: We investigated outcomes in patients with advanced non-small-cell lung cancer (NSCLC) and peritoneal involvement.

PATIENTS & METHODS: NSCLC patients with peritoneal carcinomatosis (PC) were included. We evaluated mOS1 (overall survival [OS] from NSCLC diagnosis) and mOS2 (OS from diagnosis of PC).

RESULTS: In total, 60 NSCLC patients were diagnosed with PC, 12 (20%) patients had a diagnosis of NSCLC and synchronous PC with a median OS of 9 months. Smokers had a shorter mOS1 and mOS2 compared with never-smokers; EGFR-mutated patients on tyrosine kinase inhibitors had longer mOS1 and mOS2 than EGFR wild-type patients.

CONCLUSION: Metachronous PC is correlated to a short survival, irrespective of treatment line. Never-smokers and EGFR-mutated patients had improved mOS1 and mOS2 when compared with smokers and EGFR wild-type population.

Original languageEnglish
Pages (from-to)989-994
Number of pages6
JournalFuture oncology (London, England)
Volume15
Issue number9
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols/pharmacology
  • Carcinoma, Non-Small-Cell Lung/drug therapy
  • ErbB Receptors/antagonists & inhibitors
  • Female
  • Humans
  • Lung Neoplasms/drug therapy
  • Male
  • Middle Aged
  • Mutation
  • Non-Smokers/statistics & numerical data
  • Peritoneal Neoplasms/drug therapy
  • Progression-Free Survival
  • Protein Kinase Inhibitors/pharmacology
  • Retrospective Studies
  • Sex Factors
  • Smokers/statistics & numerical data

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  • Cite this

    Abbate, M. I., Cortinovis, D. L., Tiseo, M., Vavalà, T., Cerea, G., Toschi, L., Canova, S., Colonese, F., & Bidoli, P. (2019). Peritoneal carcinomatosis in non-small-cell lung cancer: retrospective multicentric analysis and literature review. Future oncology (London, England), 15(9), 989-994. https://doi.org/10.2217/fon-2018-0469