Peritoneal dialysis in infants: The experience of the Italian Registry of Paediatric Chronic Dialysis

Enrico Vidal, Alberto Edefonti, Luisa Murer, Bruno Gianoglio, Silvio Maringhini, Carmine Pecoraro, Palma Sorino, Giovanna Leozappa, Giancarlo Lavoratti, Ilse Maria Ratsch, Roberto Chimenz, Enrico Verrina

Research output: Contribution to journalArticlepeer-review

Abstract

Background.Although chronic peritoneal dialysis (CPD) is considered the replacement therapy of choice for infants with end-stage renal failure, many questions persist about treatment risks and outcomes. Methods.We present data on 84 infants who started CPD at 2 = 0.36) and dialysis session length (R 2 = 0.35), while a negative association was found with the number of peritonitis cases (P = 0.003). Peritonitis incidence was 1:20.7 episode:CPD-months (1:28.3 in the older children from the same registry) and was significantly higher in children with oligoanuria (1:15.5 episode:CPD-months) compared to infants with residual renal function (1:37.4 episode:CPD-months). Catheter survival rate was 70% at 12 months and 51% at 24 months. Catheter-related complications were similar in infants and older children (1:20.5 versus 1:19.8 episode:CPD-months), while clinical complications were more frequent in children under 1 year of age (1:18.3 versus 1:25.2 episode:CPD-months; P <0.05). During the follow-up period, 33 patients were transplanted (39.3%), 18 were shifted to haemodialysis (21.4%) and 8 died (9.5%). The mortality rate was 4-fold greater than in older children (2.3%). Conclusions.Our data confirm that infants on CPD represent a high-risk group; however, our experience demonstrated that growth was acceptable and a large portion was successfully transplanted. Increased efforts should be aimed at optimizing dialysis efficiency and preventing peritonitis. The higher mortality rate in infants was largely caused by comorbidities.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalNephrology Dialysis Transplantation
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • complications
  • growth
  • infants
  • outcome
  • peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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