Peritoneal mesothelioma with residential asbestos exposure. Report of a case with long survival (seventeen years) analyzed by Cgh-array

Gabriella Serio, Federica Pezzuto, Andrea Marzullo, Anna Scattone, Domenica Cavone, Alessandra Punzi, Francesco Fortarezza, Mattia Gentile, Antonia Lucia Buonadonna, Mattia Barbareschi, Luigi Vimercati

Research output: Contribution to journalArticle

Abstract

Malignant mesothelioma is a rare and aggressive tumor with limited therapeutic options. We report a case of a malignant peritoneal mesothelioma (MPM) epithelioid type, with environmental asbestos exposure, in a 36-year-old man, with a long survival (17 years). The patient received standard treatment which included cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods and Results: Molecular analysis with comparative genomic hybridization (CGH)-array was performed on paraffin-embedded tumoral samples. Multiple chromosomal imbalances were detected. The gains were prevalent. Losses at 1q21, 2q11.1→q13, 8p23.1, 9p12→p11, 9q21.33→q33.1, 9q12→q21.33, and 17p12→p11.2 are observed. Chromosome band 3p21 (BAP1), 9p21 (CDKN2A) and 22q12 (NF2) are not affected. Conclusions: the defects observed in this case are uncommon in malignant peritoneal mesothelioma. Some chromosomal aberrations that appear to be random here, might actually be relevant events explaining the response to therapy, the long survival and, finally, may be considered useful prognostic factors in peritoneal malignant mesothelioma (PMM).

Original languageEnglish
Article numberE1818
Number of pages8
JournalInternational Journal of Molecular Sciences
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 22 2017

Fingerprint

asbestos
Asbestos
Chemotherapy
Mesothelioma
Chromosomes
Aberrations
Paraffin
Paraffins
Surgery
Tumors
Defects
Survival
chromosomes
paraffins
chemotherapy
surgery
aberration
therapy
tumors
Comparative Genomic Hybridization

Keywords

  • Asbestos
  • Mesothelioma
  • Molecular-array
  • Peritoneum

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Peritoneal mesothelioma with residential asbestos exposure. Report of a case with long survival (seventeen years) analyzed by Cgh-array. / Serio, Gabriella; Pezzuto, Federica; Marzullo, Andrea; Scattone, Anna; Cavone, Domenica; Punzi, Alessandra; Fortarezza, Francesco; Gentile, Mattia; Buonadonna, Antonia Lucia; Barbareschi, Mattia; Vimercati, Luigi.

In: International Journal of Molecular Sciences, Vol. 18, No. 8, E1818, 22.08.2017.

Research output: Contribution to journalArticle

Serio, G, Pezzuto, F, Marzullo, A, Scattone, A, Cavone, D, Punzi, A, Fortarezza, F, Gentile, M, Buonadonna, AL, Barbareschi, M & Vimercati, L 2017, 'Peritoneal mesothelioma with residential asbestos exposure. Report of a case with long survival (seventeen years) analyzed by Cgh-array', International Journal of Molecular Sciences, vol. 18, no. 8, E1818. https://doi.org/10.3390/ijms18081818
Serio, Gabriella ; Pezzuto, Federica ; Marzullo, Andrea ; Scattone, Anna ; Cavone, Domenica ; Punzi, Alessandra ; Fortarezza, Francesco ; Gentile, Mattia ; Buonadonna, Antonia Lucia ; Barbareschi, Mattia ; Vimercati, Luigi. / Peritoneal mesothelioma with residential asbestos exposure. Report of a case with long survival (seventeen years) analyzed by Cgh-array. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 8.
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