Abstract
| Original language | English |
|---|---|
| Journal | Front. Immunol. |
| Volume | 11 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- CD4
- CD8
- human leukocyte antigen class I antigens
- prognosis
- programmed death-ligand 1
- thin melanoma
- time
- tumor-infiltrating lymphocytes
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Peritumoral Immune Infiltrate as a Prognostic Biomarker in Thin Melanoma : Frontiers in Immunology. / Sabbatino, F.; Scognamiglio, G.; Liguori, L.; Marra, A.; Anniciello, A.M.; Polcaro, G.; Dal Col, J.; Caputo, A.; Peluso, A.L.; Botti, G.; Zeppa, P.; Ferrone, S.; Pepe, S.
In: Front. Immunol., Vol. 11, 2020.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Peritumoral Immune Infiltrate as a Prognostic Biomarker in Thin Melanoma
T2 - Frontiers in Immunology
AU - Sabbatino, F.
AU - Scognamiglio, G.
AU - Liguori, L.
AU - Marra, A.
AU - Anniciello, A.M.
AU - Polcaro, G.
AU - Dal Col, J.
AU - Caputo, A.
AU - Peluso, A.L.
AU - Botti, G.
AU - Zeppa, P.
AU - Ferrone, S.
AU - Pepe, S.
N1 - Export Date: 5 March 2021 Correspondence Address: Sabbatino, F.; Department of Medicine, Italy; email: fsabbatino@unisa.it Correspondence Address: Sabbatino, F.; Oncology Unit, Italy; email: fsabbatino@unisa.it Funding details: CODICE 2017PHRC8X_003 Funding text 1: The work was supported by Ministero dell’ Università e della Ricerca (Progetti di Rilevante Interesse Nazionale (PRIN), 2017, CODICE 2017PHRC8X_003) (to SP). 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PY - 2020
Y1 - 2020
N2 - Thin melanomas are tumors less than 1 mm thick according to Breslow classification. Their prognosis is in most cases excellent. However, a small subset of these tumors relapses. These clinical findings emphasize the need of novel prognostic biomarkers to identify this subset of tumors. Characterization of tumor immune microenvironment (TIME) is currently investigated as a prognostic and predictive biomarker for cancer immunotherapy in several solid tumors including melanoma. Here, taking into account the limited availability of tumor tissues, by characterizing some of the characteristics of TIME such as number of infiltrating lymphocytes, HLA class I antigen and PD-L1 expression, we show that number of infiltrating CD8+ and FOXP3+ T cells as well as CD8+/FOXP3+ T cell ratio can represent a useful prognostic biomarker in thin melanoma. Although further investigations in a larger patient cohort are needed, these findings have potential clinical significance since they can be used to define subgroups of thin melanoma patients who have a worse prognosis and might need different treatment modalities. © Copyright © 2020 Sabbatino, Scognamiglio, Liguori, Marra, Anniciello, Polcaro, Dal Col, Caputo, Peluso, Botti, Zeppa, Ferrone and Pepe.
AB - Thin melanomas are tumors less than 1 mm thick according to Breslow classification. Their prognosis is in most cases excellent. However, a small subset of these tumors relapses. These clinical findings emphasize the need of novel prognostic biomarkers to identify this subset of tumors. Characterization of tumor immune microenvironment (TIME) is currently investigated as a prognostic and predictive biomarker for cancer immunotherapy in several solid tumors including melanoma. Here, taking into account the limited availability of tumor tissues, by characterizing some of the characteristics of TIME such as number of infiltrating lymphocytes, HLA class I antigen and PD-L1 expression, we show that number of infiltrating CD8+ and FOXP3+ T cells as well as CD8+/FOXP3+ T cell ratio can represent a useful prognostic biomarker in thin melanoma. Although further investigations in a larger patient cohort are needed, these findings have potential clinical significance since they can be used to define subgroups of thin melanoma patients who have a worse prognosis and might need different treatment modalities. © Copyright © 2020 Sabbatino, Scognamiglio, Liguori, Marra, Anniciello, Polcaro, Dal Col, Caputo, Peluso, Botti, Zeppa, Ferrone and Pepe.
KW - CD4
KW - CD8
KW - human leukocyte antigen class I antigens
KW - prognosis
KW - programmed death-ligand 1
KW - thin melanoma
KW - time
KW - tumor-infiltrating lymphocytes
U2 - 10.3389/fimmu.2020.561390
DO - 10.3389/fimmu.2020.561390
M3 - Article
VL - 11
JO - Front. Immunol.
JF - Front. Immunol.
SN - 1664-3224
ER -