Perivascular multi-lineage progenitor cells in human organs: Regenerative units, cytokine sources or both?

Chien Wen Chen, Elisa Montelatici, Mihaela Crisan, Mirko Corselli, Johnny Huard, Lorenza Lazzari, Bruno Péault

Research output: Contribution to journalArticle

Abstract

Multi-lineage progenitors, e.g. mesenchymal stem cells, persist in adult developed organs, making a windfall for the cell therapist but an enigma for stem cell biologists. Recent results from our own and other laboratories show that the ancestor of these elusive adult stem cells is likely to be found in the perivascular area, explaining the ubiquitous distribution of these cells in the body. We have prospectively identified and purified vascular pericytes in multiple human organs and shown that these cells are potent mesodermal progenitors that give rise to genuine mesenchymal stem cells in culture. Pericytes can differentiate into diverse cell lineages, but also secrete multiple paracrine growth factors/cytokines, which likely explains in part their robust regenerative potential.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalCytokine and Growth Factor Reviews
Volume20
Issue number5-6
DOIs
Publication statusPublished - Oct 2009

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Keywords

  • Angiogenesis
  • Heart infarction
  • Mesenchymal stem cell
  • Pericyte
  • Tissue regeneration

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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