Perivascular multipotent progenitor cells in human organs

Mihaela Crisan, Chien Wen Chen, Mirko Corselli, Gabriella Andriolo, Lorenza Lazzari, Bruno Péault

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-Rβ, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages118-123
Number of pages6
Volume1176
DOIs
Publication statusPublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1176
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Mesenchymal stem cell
  • Pericyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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