Periventricular leukomalacia specifically affects cortical MEG response to biological motion

Marina Pavlova; Fabio Marconato; Alexander Sokolov; Christoph Braun; Niels Birbaumer; Ingeborg Krägeloh-Mann

doi:10.1002/ana.20762

Periventricular leukomalacia specifically affects cortical MEG response to biological motion

Marina Pavlova, Fabio Marconato, Alexander Sokolov, Christoph Braun, Niels Birbaumer, Ingeborg Krägeloh-Mann

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity. Methods: Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL. Results: Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls. Interpretation: This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.

Original language	English
Pages (from-to)	415-419
Number of pages	5
Journal	Annals of Neurology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1002/ana.20762
Publication status	Published - Feb 2006

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/ana.20762

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abstract = "Objective: Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity. Methods: Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL. Results: Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls. Interpretation: This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.",

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T1 - Periventricular leukomalacia specifically affects cortical MEG response to biological motion

AU - Pavlova, Marina

AU - Marconato, Fabio

AU - Sokolov, Alexander

AU - Braun, Christoph

AU - Birbaumer, Niels

AU - Krägeloh-Mann, Ingeborg

PY - 2006/2

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N2 - Objective: Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity. Methods: Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL. Results: Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls. Interpretation: This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.

AB - Objective: Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity. Methods: Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL. Results: Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls. Interpretation: This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.

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Periventricular leukomalacia specifically affects cortical MEG response to biological motion

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