Periventricular leukomalacia specifically affects cortical MEG response to biological motion

Marina Pavlova, Fabio Marconato, Alexander Sokolov, Christoph Braun, Niels Birbaumer, Ingeborg Krägeloh-Mann

Research output: Contribution to journalArticlepeer-review


Objective: Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity. Methods: Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL. Results: Dynamics of MEG activity parallel behavioral deficits. Early (140-170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls. Interpretation: This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalAnnals of Neurology
Issue number2
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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