TY - JOUR
T1 - Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression
AU - Pompili, Maurizio
AU - Innamorati, Marco
AU - Mann, J. John
AU - Oquendo, Maria A.
AU - Lester, David
AU - Del Casale, Antonio
AU - Serafini, Gianluca
AU - Rigucci, Silvia
AU - Romano, Andrea
AU - Tamburello, Antonino
AU - Manfredi, Giovanni
AU - De Pisa, Eleonora
AU - Ehrlich, Stefan
AU - Giupponi, Giancarlo
AU - Amore, Mario
AU - Tatarelli, Roberto
AU - Girardi, Paolo
PY - 2008/8/1
Y1 - 2008/8/1
N2 - The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD = 15.2; Min./Max. = 19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH-the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.
AB - The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD = 15.2; Min./Max. = 19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH-the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.
KW - Bipolar disorder
KW - Major affective disorders
KW - Major depressive disorder
KW - Suicide
KW - White matter hyperintensities
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UR - http://www.scopus.com/inward/citedby.url?scp=47749083056&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2008.05.009
DO - 10.1016/j.pnpbp.2008.05.009
M3 - Article
C2 - 18572296
AN - SCOPUS:47749083056
VL - 32
SP - 1501
EP - 1507
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 6
ER -