Permanent Consequences in Langerhans Cell Histiocytosis Patients: A Pilot Study from the Histiocyte Society - Late Effects Study Group

Riccardo Haupt, Vasanta Nanduri, Maria Grazia Calevo, Cecilia Bernstrand, Jorge L. Braier, Valerie Broadbent, Guadalupe Rey, Kenneth L. McClain, Gritta Janka-Schaub, R. Maarten Egeler

Research output: Contribution to journalArticle

Abstract

Background. Permanent consequences (PC) are often described among subjects with Langerhans cell histiocytosis (LCH) but data on the real incidence are scarce. Within the Histiocyte Society (HS), and in order to design a definitive late effects study, a retrospective survey was organized to describe the prevalence of PC among long-term survivors of LCH. Methods. Nine institutions contributed with their LCH patients having a minimum follow-up of 3 years. Information was collected on their disease-history, and on type and date of onset of any PC. Because of the retrospective type of this study, it was accepted that each institution might have used different criteria to assess PC. Results. One hundred eighty-two subjects were registered and in 95 (52%) at least 1 PC was reported. For some specific PC (e.g., anterior pituitary dysfunction) information was too scarce to provide reliable data. PC were more frequent among subjects with multisystem (MS) disease (71%), compared to those with single system (SS) disease (24%); P

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalPediatric Blood and Cancer
Volume42
Issue number5
DOIs
Publication statusPublished - May 2004

    Fingerprint

Keywords

  • Endocrine problems
  • Langerhans cell histiocytosis
  • Long-term survivors
  • Neurological complications
  • Toxicity

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Haupt, R., Nanduri, V., Calevo, M. G., Bernstrand, C., Braier, J. L., Broadbent, V., Rey, G., McClain, K. L., Janka-Schaub, G., & Maarten Egeler, R. (2004). Permanent Consequences in Langerhans Cell Histiocytosis Patients: A Pilot Study from the Histiocyte Society - Late Effects Study Group. Pediatric Blood and Cancer, 42(5), 438-444. https://doi.org/10.1002/pbc.20021