Permanent diabetes mellitus in the first year of life.

D. Iafusco, M. A. Stazi, R. Cotichini, M. Cotellessa, M. E. Martinucci, M. Mazzella, V. Cherubini, F. Barbetti, M. Martinetti, F. Cerutti, F. Prisco

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Abstract

AIMS/HYPOTHESIS: The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes. METHODS: The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied. RESULTS: The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6). CONCLUSION/INTERPRETATION: These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.

Original languageEnglish
Pages (from-to)798-804
Number of pages7
JournalDiabetologia
Volume45
Issue number6
Publication statusPublished - Jun 2002

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Type 1 Diabetes Mellitus
Diabetes Mellitus
Insulin
Autoimmunity
Age of Onset
Genotype
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Iafusco, D., Stazi, M. A., Cotichini, R., Cotellessa, M., Martinucci, M. E., Mazzella, M., ... Prisco, F. (2002). Permanent diabetes mellitus in the first year of life. Diabetologia, 45(6), 798-804.

Permanent diabetes mellitus in the first year of life. / Iafusco, D.; Stazi, M. A.; Cotichini, R.; Cotellessa, M.; Martinucci, M. E.; Mazzella, M.; Cherubini, V.; Barbetti, F.; Martinetti, M.; Cerutti, F.; Prisco, F.

In: Diabetologia, Vol. 45, No. 6, 06.2002, p. 798-804.

Research output: Contribution to journalArticle

Iafusco, D, Stazi, MA, Cotichini, R, Cotellessa, M, Martinucci, ME, Mazzella, M, Cherubini, V, Barbetti, F, Martinetti, M, Cerutti, F & Prisco, F 2002, 'Permanent diabetes mellitus in the first year of life.', Diabetologia, vol. 45, no. 6, pp. 798-804.
Iafusco D, Stazi MA, Cotichini R, Cotellessa M, Martinucci ME, Mazzella M et al. Permanent diabetes mellitus in the first year of life. Diabetologia. 2002 Jun;45(6):798-804.
Iafusco, D. ; Stazi, M. A. ; Cotichini, R. ; Cotellessa, M. ; Martinucci, M. E. ; Mazzella, M. ; Cherubini, V. ; Barbetti, F. ; Martinetti, M. ; Cerutti, F. ; Prisco, F. / Permanent diabetes mellitus in the first year of life. In: Diabetologia. 2002 ; Vol. 45, No. 6. pp. 798-804.
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