Permanent polymer of drug eluting stents increases eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein

Giampaolo Niccoli, Camilla Calvieri, Silvia Minelli, Giorgia Copponi, Rocco Montone, Asiya Imaeva, Marco Roberto, Nicola Cosentino, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Aim: To assess eosinophil cationic protein (ECP) and C-reactive protein (CRP) serum levels at three time points according to different stent types. Methods: 54 patients (age 64±10 years, male 78%), undergoing Bare Metal Stent (BMS) (n=11), mammalian Target Of Rapamycin (mTOR)-inhibitor DES (n=27) and mTOR-inhibitor bioabsorbable DES (BES) (n=16) implantation for stable angina (SA) or non-ST-elevation acute coronary syndromes (NSTE-ACS), were prospectively enrolled. ECP and CRP serum levels were assessed before revascularization, at 1-month and at 1-year after the procedure. Moreover, 21 patients found to have inducible ischemia or angina symptoms at 6 month-stress test underwent 1-year follow-up (FU) angiography. Results: Baseline and 1-month ECP levels were similar among the 3 groups, whilst 1-year ECP was significantly higher in m-TOR-DES [8.61 (6.55-19.77) μg/ml] compared with m-TOR-BES [2.03 (1.78-5.53) μg/ml] and BMS-treated patients [2.23 (1.45-8.95) μg/ml] (p=0.02), without significant difference between BES and BMS. CRP was similar among the 3 groups at all time points. 1-year ECP significantly correlated with late loss in patients undergoing FU angiography (r=0.64, p=0.002), while CRP did not (p=NS). Conclusions: Our finding suggests that mTOR-DES stent type is associated with an increase of ECP levels at 1-year, possibly reflecting a persistent eosinophil activation triggered by permanent polymer.

Original languageEnglish
Pages (from-to)816-820
Number of pages5
JournalAtherosclerosis
Volume237
Issue number2
DOIs
Publication statusPublished - Dec 1 2014

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Keywords

  • Bare metal stent or drug-eluting stent
  • ECP
  • Inflammatory markers
  • Permanent polymer

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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