Abstract
Two different forms of synaptic plasticity have been found at corticostriatal synapses: long-term depression (LTD) and long-term potentiation (LTP). Both these enduring changes in the efficacy of excitatory neurotransmission in the striatum have a major impact on the physiological activity of the basal ganglia and are triggered by the stimulation of complex and independent cascades of intracellular second messenger systems. Striatal LTD and LTP are evoked following the repetitive stimulation of corticostriatal fibers and are dependent on the glutamate ionotropic receptor subtype activated. Recent experimental evidence indicates that two different subtypes of interneurons attend in the correct processing of information flow arising from the cortex and leading to striatal LTD or LTP. Acetylcholine (Ach) and nitric oxide (NO) producing striatal interneurons, in fact, are activated by the cortex during the induction phase of striatal plasticity, and stimulate, in turn, the intracellular changes in projection neurons required for LTD or LTP. Interneurons, therefore, exerts a feed-forward control of the excitability of striatal projection neurons ensuring the coordinate expression of two alternative forms of synaptic plasticity at the same type of excitatory synapse.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Brain Research Reviews |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1999 |
Fingerprint
Keywords
- Acetylcholine
- Long-term depression
- Long-term potentiation
- Nitric oxide
- Striatum
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Permissive role of interneurons in corticostriatal synaptic plasticity. / Centonze, Diego; Gubellini, Paolo; Bernardi, Giorgio; Calabresi, Paolo.
In: Brain Research Reviews, Vol. 31, No. 1, 1999, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Permissive role of interneurons in corticostriatal synaptic plasticity
AU - Centonze, Diego
AU - Gubellini, Paolo
AU - Bernardi, Giorgio
AU - Calabresi, Paolo
PY - 1999
Y1 - 1999
N2 - Two different forms of synaptic plasticity have been found at corticostriatal synapses: long-term depression (LTD) and long-term potentiation (LTP). Both these enduring changes in the efficacy of excitatory neurotransmission in the striatum have a major impact on the physiological activity of the basal ganglia and are triggered by the stimulation of complex and independent cascades of intracellular second messenger systems. Striatal LTD and LTP are evoked following the repetitive stimulation of corticostriatal fibers and are dependent on the glutamate ionotropic receptor subtype activated. Recent experimental evidence indicates that two different subtypes of interneurons attend in the correct processing of information flow arising from the cortex and leading to striatal LTD or LTP. Acetylcholine (Ach) and nitric oxide (NO) producing striatal interneurons, in fact, are activated by the cortex during the induction phase of striatal plasticity, and stimulate, in turn, the intracellular changes in projection neurons required for LTD or LTP. Interneurons, therefore, exerts a feed-forward control of the excitability of striatal projection neurons ensuring the coordinate expression of two alternative forms of synaptic plasticity at the same type of excitatory synapse.
AB - Two different forms of synaptic plasticity have been found at corticostriatal synapses: long-term depression (LTD) and long-term potentiation (LTP). Both these enduring changes in the efficacy of excitatory neurotransmission in the striatum have a major impact on the physiological activity of the basal ganglia and are triggered by the stimulation of complex and independent cascades of intracellular second messenger systems. Striatal LTD and LTP are evoked following the repetitive stimulation of corticostriatal fibers and are dependent on the glutamate ionotropic receptor subtype activated. Recent experimental evidence indicates that two different subtypes of interneurons attend in the correct processing of information flow arising from the cortex and leading to striatal LTD or LTP. Acetylcholine (Ach) and nitric oxide (NO) producing striatal interneurons, in fact, are activated by the cortex during the induction phase of striatal plasticity, and stimulate, in turn, the intracellular changes in projection neurons required for LTD or LTP. Interneurons, therefore, exerts a feed-forward control of the excitability of striatal projection neurons ensuring the coordinate expression of two alternative forms of synaptic plasticity at the same type of excitatory synapse.
KW - Acetylcholine
KW - Long-term depression
KW - Long-term potentiation
KW - Nitric oxide
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=0033408476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033408476&partnerID=8YFLogxK
U2 - 10.1016/S0165-0173(99)00018-1
DO - 10.1016/S0165-0173(99)00018-1
M3 - Article
C2 - 10611492
AN - SCOPUS:0033408476
VL - 31
SP - 1
EP - 5
JO - Brain Research Reviews
JF - Brain Research Reviews
SN - 0165-0173
IS - 1
ER -