TY - JOUR
T1 - Permutation entropy of scalp EEG
T2 - A tool to investigate epilepsies. Suggestions from absence epilepsies.
AU - Ferlazzo, Edoardo
AU - Mammone, Nadia
AU - Cianci, Vittoria
AU - Gasparini, Sara
AU - Gambardella, Antonio
AU - Labate, Angelo
AU - Latella, Maria Adele
AU - Sofia, Vito
AU - Elia, Maurizio
AU - Morabito, Francesco Carlo
AU - Aguglia, Umberto
PY - 2014/1
Y1 - 2014/1
N2 - Objective: We used permutation entropy (PE) to disclose abnormalities of cerebral activity in patients with typical absences (TAs). Methods: We evaluated 24 EEG of TA patients and 40 EEG of healthy subjects. PE was estimated channel by channel, with electrodes being divided into high-PE cluster (high randomness), low-PE cluster (low randomness), and neutral cluster. We compared PE between EEG of patients and controls, and between interictal and ictal EEG of patients. Results: Patients showed a recurrent behavior of PE topography, with anterior brain regions constantly associated to high PE levels and posterior brain regions constantly associated to low PE levels, during both interictal and ictal phases. On the contrary, healthy controls had a random distribution of PE topography. Conclusions: In patients with TAs, a higher randomness in fronto-temporal areas and a lower randomness in posterior areas occur during both interictal and ictal phases. Such abnormalities are in keeping with evidences from different morphological and functional studies showing multifocal brain changes in TA patients. Significance: PE seems to be a useful tool to disclose abnormalities of cerebral electric activity not revealed by conventional EEG recordings, opening interesting prospective for future studies.
AB - Objective: We used permutation entropy (PE) to disclose abnormalities of cerebral activity in patients with typical absences (TAs). Methods: We evaluated 24 EEG of TA patients and 40 EEG of healthy subjects. PE was estimated channel by channel, with electrodes being divided into high-PE cluster (high randomness), low-PE cluster (low randomness), and neutral cluster. We compared PE between EEG of patients and controls, and between interictal and ictal EEG of patients. Results: Patients showed a recurrent behavior of PE topography, with anterior brain regions constantly associated to high PE levels and posterior brain regions constantly associated to low PE levels, during both interictal and ictal phases. On the contrary, healthy controls had a random distribution of PE topography. Conclusions: In patients with TAs, a higher randomness in fronto-temporal areas and a lower randomness in posterior areas occur during both interictal and ictal phases. Such abnormalities are in keeping with evidences from different morphological and functional studies showing multifocal brain changes in TA patients. Significance: PE seems to be a useful tool to disclose abnormalities of cerebral electric activity not revealed by conventional EEG recordings, opening interesting prospective for future studies.
KW - Absences
KW - Brain topography
KW - EEG
KW - Permutation entropy
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U2 - 10.1016/j.clinph.2013.06.023
DO - 10.1016/j.clinph.2013.06.023
M3 - Article
C2 - 23859939
AN - SCOPUS:84890216072
VL - 125
SP - 13
EP - 20
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 1
ER -