Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis

Thrasivoulos G. Tzellos, Dimitrios K. Tahmatzidis, Aimilios Lallas, Kiriaki Apostolidou, Dimitrios G. Goulis

Research output: Contribution to journalArticle

Abstract

A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious anaemia and gastric carcinoids in DMT1 patients. Screening for AGPA followed by serum gastrin and vitamin B12 levels constitute the most evidence-based diagnostic approach.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalJournal of Diabetes and its Complications
Volume23
Issue number6
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Alopecia Areata
Pernicious Anemia
Type 1 Diabetes Mellitus
Carcinoid Tumor
Schilling Test
Atrophic Gastritis
Addison Disease
Gastroscopy
Intrinsic Factor
Thyroid Diseases
Gastrins
Vitamin B 12
Ambulatory Care Facilities
Dyspnea
Fatigue
Stomach
Alopecia universalis
Antibodies
Serum

Keywords

  • Alopecia areata universalis
  • Diabetes mellitus Type 1
  • Pernicious anemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis. / Tzellos, Thrasivoulos G.; Tahmatzidis, Dimitrios K.; Lallas, Aimilios; Apostolidou, Kiriaki; Goulis, Dimitrios G.

In: Journal of Diabetes and its Complications, Vol. 23, No. 6, 11.2009, p. 434-437.

Research output: Contribution to journalArticle

Tzellos, Thrasivoulos G. ; Tahmatzidis, Dimitrios K. ; Lallas, Aimilios ; Apostolidou, Kiriaki ; Goulis, Dimitrios G. / Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis. In: Journal of Diabetes and its Complications. 2009 ; Vol. 23, No. 6. pp. 434-437.
@article{89557774c3994426b0f41b6f0cd7d200,
title = "Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis",
abstract = "A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious anaemia and gastric carcinoids in DMT1 patients. Screening for AGPA followed by serum gastrin and vitamin B12 levels constitute the most evidence-based diagnostic approach.",
keywords = "Alopecia areata universalis, Diabetes mellitus Type 1, Pernicious anemia",
author = "Tzellos, {Thrasivoulos G.} and Tahmatzidis, {Dimitrios K.} and Aimilios Lallas and Kiriaki Apostolidou and Goulis, {Dimitrios G.}",
year = "2009",
month = "11",
doi = "10.1016/j.jdiacomp.2008.05.003",
language = "English",
volume = "23",
pages = "434--437",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis

AU - Tzellos, Thrasivoulos G.

AU - Tahmatzidis, Dimitrios K.

AU - Lallas, Aimilios

AU - Apostolidou, Kiriaki

AU - Goulis, Dimitrios G.

PY - 2009/11

Y1 - 2009/11

N2 - A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious anaemia and gastric carcinoids in DMT1 patients. Screening for AGPA followed by serum gastrin and vitamin B12 levels constitute the most evidence-based diagnostic approach.

AB - A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious anaemia and gastric carcinoids in DMT1 patients. Screening for AGPA followed by serum gastrin and vitamin B12 levels constitute the most evidence-based diagnostic approach.

KW - Alopecia areata universalis

KW - Diabetes mellitus Type 1

KW - Pernicious anemia

UR - http://www.scopus.com/inward/record.url?scp=70350506560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350506560&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2008.05.003

DO - 10.1016/j.jdiacomp.2008.05.003

M3 - Article

C2 - 18614380

AN - SCOPUS:70350506560

VL - 23

SP - 434

EP - 437

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 6

ER -