Peroxisome proliferator-activated receptor-α agonists modulate CXCL9 and CXCL11 chemokines in Graves' ophthalmopathy fibroblasts and preadipocytes

Alessandro Antonelli, Silvia Martina Ferrari, Silvia Frascerra, Ilaria Ruffilli, Stefania Gelmini, Michele Minuto, Cinzia Pupilli, Paolo Miccoli, Stefano Sellari-Franceschini, Ele Ferrannini, Poupak Fallahi

Research output: Contribution to journalArticle

Abstract

Peroxisome proliferator-activated receptors (PPAR)α have been shown to exert immunomodulatory effects in autoimmune disorders; no study evaluated the effect of PPARα activation in Graves' ophthalmopathy (GO).We show the presence of PPARα, δ and γ in GO fibroblasts and preadipocytes. PPARα activators have a potent inhibitory action on the secretion of CXCL9 and CXCL11 chemokines (induced by IFNγ and TNFα) in fibroblasts and preadipocytes. The potency of the used PPARα agonists was maximum on the secretion of CXCL11 (67% inhibition by fenofibrate) in fibroblasts. The relative potency of the compounds in GO fibroblasts was different with each chemokine. PPARα agonists were stronger inhibitors of CXCL9 and CXCL11 (in GO fibroblasts and preadipocytes) than PPARγ activators.This study first shows that PPARα activators inhibit CXCL9 and CXCL11 chemokines in normal and GO fibroblasts and preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume349
Issue number2
DOIs
Publication statusPublished - Feb 26 2012

Keywords

  • CXCL11
  • CXCL9
  • Cytokines
  • Fibroblasts
  • Graves' ophthalmopathy
  • PPARα

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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  • Cite this

    Antonelli, A., Ferrari, S. M., Frascerra, S., Ruffilli, I., Gelmini, S., Minuto, M., Pupilli, C., Miccoli, P., Sellari-Franceschini, S., Ferrannini, E., & Fallahi, P. (2012). Peroxisome proliferator-activated receptor-α agonists modulate CXCL9 and CXCL11 chemokines in Graves' ophthalmopathy fibroblasts and preadipocytes. Molecular and Cellular Endocrinology, 349(2), 255-261. https://doi.org/10.1016/j.mce.2011.11.001