Peroxisome proliferator-activated receptor-α modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice

Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocrea

Research output: Contribution to journalArticle

Abstract

Glucocorticoids (GCs) are effective anti-inflammatory agents widely used in therapeutic approach to treatment of inflammatory bowel disease (IBD). Previous results suggest that peroxisome proliferator-activated receptor α (PPAR-α), an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation. With the aim to characterize the role of PPAR-α in GC-mediated anti-inflammatory activity, we tested the efficacy of dexamethasone (DEX), a synthetic GC specific for GR, in an experimental model of IBD induced by dinitrobenzene sulfonic acid, comparing mice lacking PPAR-α (PPAR-αKO) with wild-type (WT) mice. Results indicate that DEX-mediated antiinflammatory activity is weakened in PPAR-αKO mice as compared with WT controls. In particular, DEX was less effective in PPAR-αKO compared with WT mice, as evaluated by inhibition of proinflammatory cytokines production, cell migration, oxidative stress, apoptosis, and colon injury. These results indicate that PPAR-α can contribute to the anti-inflammatory activity of GCs in IBD.

Original languageEnglish
Pages (from-to)308-316
Number of pages9
JournalShock
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Bowel disease
  • Cytokines
  • Dexamethasone
  • Glucocorticoids
  • Ppar-α

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Medicine(all)

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    Riccardi, L., Mazzon, E., Bruscoli, S., Esposito, E., Crisafulli, C., Paola, R. D., Caminiti, R., Riccardi, C., & Cuzzocrea, S. (2009). Peroxisome proliferator-activated receptor-α modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock, 31(3), 308-316. https://doi.org/10.1097/SHK.0b013e31818339e7