Peroxisome Proliferator-Activated Receptor Gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer

Athina Stravodimou, Gianluigi Mazzoccoli, Ioannis A. Voutsadakis

Research output: Contribution to journalArticle


Pancreatic cancer is one of the most lethal forms of human cancer. Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remains grim. Several molecular abnormalities often present in pancreatic cancer have been defined and include mutations in K-ras, p53, p16, and DPC4 genes. Nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPARγ) has a role in many carcinomas and has been found to be overexpressed in pancreatic cancer. It plays generally a tumor suppressor role antagonizing proteins promoting carcinogenesis such as NF-κB and TGFβ. Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS). This paper will examine PPARγ in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.

Original languageEnglish
Article number367450
JournalPPAR Research
Publication statusPublished - 2012


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Drug Discovery

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