"Peroxisome proliferator activated receptors" e patologie cardiovascolari

Translated title of the contribution: Peroxisome proliferator activated receptors and cardiovascular disease

Giuseppe Danilo Norata, Fabio Pellegatta, Alberico Luigi Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

Peroxisome proliferator activated receptors (PPARs) are transcription factors only recently discovered. Nevertheless, the interest surrounding their study has involved and involves a continuously growing number of researchers. This is due to the role that PPARs play in the understanding of the pathophysiology of clinical conditions such as obesity, diabetes, atherosclerosis, and angiogenesis. Lipid and glucidic metabolism, synthesis of cytokines, adhesion molecules, coagulation factors, fibrinolysis, are only few of the several processes controlled by PPARs. In this review the more recent acquisitions on PPAR mechanisms of action will be described. The clinical implications that their activation/deactivation induce will be also evaluated. Particular emphasis will be placed on their role in the control of the physiology of lipid and glucidic metabolism, as well as in the pathophysiology of inflammatory and atherosclerotic processes.

Translated title of the contributionPeroxisome proliferator activated receptors and cardiovascular disease
Original languageItalian
Pages (from-to)8-18
Number of pages11
JournalItalian Heart Journal Supplement
Volume4
Issue number1
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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