Abstract
The importance of peroxisomes for human health is highlighted by the number of peroxisomal disorders (PDs), diseases associated to peroxisome biogenesis disorders and peroxisomal enzyme/transporter deficiencies. Currently, many physiological/biosynthetic mechanisms involved in these illnesses have been elucidated, but PDs remain incurable. This review examines the most important aspects concerning peroxisomes (i.e. peroxisome proliferation, peroxisome biogenesis, metabolic functions of mammalian peroxisomes) and presents the most significant trends and advances in the study of peroxisomal disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 615-625 |
| Number of pages | 11 |
| Journal | Experimental and Toxicologic Pathology |
| Volume | 62 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2010 |
Keywords
- Peroxisomal Β-oxidation
- Peroxisomal biogenesis
- Peroxisomal disorders
- Peroxisomal metabolism
- Peroxisomes
ASJC Scopus subject areas
- Cell Biology
- Pathology and Forensic Medicine
- Toxicology
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Cite this
Fidaleo, M. (2010). Peroxisomes and peroxisomal disorders: The main facts. Experimental and Toxicologic Pathology, 62(6), 615-625. https://doi.org/10.1016/j.etp.2009.08.008