Persistence of Candida albicans candidemia in non-neutropenic surgical patients: Management of a representative patient in the absence of second-line treatment guidelines

D. Pacini, M. Cerana, A. Beltrame, A. Di Biagio, Andrea De Maria

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Primary treatment failure and mortality in non-neutropenic patients with candidemia is high according to clinical trial experience. Current guidelines are mainly useful only for first line treatment strategies. We describe treatment failure and persistent protracted Candida albicans candidemia without clinically evident ocular involvement nor catheter recolonization in a malnourished non-neutropenic surgical patient with peritonitis. Primary antifungal treatment failure with fluconazole and secondary treatment failure with caspofungin occurred in the absence of evident Candida seeding the eye, valvular endocardium, or the intravascular catheter. Switch to liposomal amphotericin B was followed by clinical and microbiological cure. In patients with multiple risk factors for the acquisition of candidemia and life-threatening clinical conditions, the possibility of primary/secondary failure of new potent antifungal regimens may be initially neglected. Additional multicenter controlled clinical data are needed to guide the timing and choice of secondary antifungal treatment regimens in non-neutropenic candidemia patients.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalJournal of Chemotherapy
Issue number3
Publication statusPublished - Jun 2007



  • Antifungal treatment
  • Candida albicans
  • Candidemia
  • Sepsis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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