TY - JOUR
T1 - Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia
AU - Zaccaria, Alfonso
AU - Valenti, Anna Maria
AU - Donti, Emilio
AU - Gozzetti, Alessandro
AU - Ronconi, Sonia
AU - Spedicato, Francesco
PY - 2007/4
Y1 - 2007/4
N2 - Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.
AB - Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.
KW - Additional abnormalities
KW - Imatinib resistance
KW - Pathogenesis
KW - Ph
UR - http://www.scopus.com/inward/record.url?scp=34547691666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547691666&partnerID=8YFLogxK
U2 - 10.3324/haematol.10783
DO - 10.3324/haematol.10783
M3 - Article
C2 - 17488671
AN - SCOPUS:34547691666
VL - 92
SP - 564
EP - 565
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 4
ER -