Abstract
Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.
| Original language | English |
|---|---|
| Pages (from-to) | 564-565 |
| Number of pages | 2 |
| Journal | Haematologica |
| Volume | 92 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2007 |
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Keywords
- Additional abnormalities
- Imatinib resistance
- Pathogenesis
- Ph
ASJC Scopus subject areas
- Hematology
Cite this
Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia. / Zaccaria, Alfonso; Valenti, Anna Maria; Donti, Emilio; Gozzetti, Alessandro; Ronconi, Sonia; Spedicato, Francesco.
In: Haematologica, Vol. 92, No. 4, 04.2007, p. 564-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia
AU - Zaccaria, Alfonso
AU - Valenti, Anna Maria
AU - Donti, Emilio
AU - Gozzetti, Alessandro
AU - Ronconi, Sonia
AU - Spedicato, Francesco
PY - 2007/4
Y1 - 2007/4
N2 - Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.
AB - Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.
KW - Additional abnormalities
KW - Imatinib resistance
KW - Pathogenesis
KW - Ph
UR - http://www.scopus.com/inward/record.url?scp=34547691666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547691666&partnerID=8YFLogxK
U2 - 10.3324/haematol.10783
DO - 10.3324/haematol.10783
M3 - Article
C2 - 17488671
AN - SCOPUS:34547691666
VL - 92
SP - 564
EP - 565
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 4
ER -