Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia

Alfonso Zaccaria, Anna Maria Valenti, Emilio Donti, Alessandro Gozzetti, Sonia Ronconi, Francesco Spedicato

Research output: Contribution to journalArticlepeer-review

Abstract

Five Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either alone or together with a karyotypically normal cell population. This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities.

Original languageEnglish
Pages (from-to)564-565
Number of pages2
JournalHaematologica
Volume92
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Additional abnormalities
  • Imatinib resistance
  • Pathogenesis
  • Ph

ASJC Scopus subject areas

  • Hematology

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