Persistence of somatostatinergic tone in acromegaly

R. Attanasio, R. Cozzi, G. Oppizzi, D. Dallabonzana, I. Chiodini, Z. Benini, P. Orlandi, A. Liuzzi, P. G. Ghiodini

Research output: Contribution to journalArticlepeer-review


It is a matter of debate whether hypothalamic somatostatin (SRIH) secretion in acromegaly is preserved and still regulated by the physiological feedback mechanisms of growth hormone (GH) and insulin-like growth factor I. To gather further information on this, the reproducibility of plasma GH changes induced by growth hormone-releasing hormone (GHRH) administration was evaluated in 15 acromegalic patients. There was a highly significant correlation between the peak/basal ratio (P/B) GH response in the 15 patients administered GHRH on two separate occasions (r = 0.99, p <0.001). The test was performed also before and after the administration of drugs able to inhibit or stimulate hypothalamic SRIH release, by activating (pyridostigmine) or inhibiting (pirenzepine) cholinergic pathways, respectively. The GHRH-induced GH response (P/B = 2, range 1.1-26.1) was increased significantly by pyridostigmine pretreatment in 30 patients (P/B = 2.6, range 1.3-34.8; p = 0.0045). In nine out of 30 patients an increase of greater than 2 SD of within-subject GHRH variability was observed in response to GHRH plus pyridostigmine when compared to GHRH alone. An inverse correlation (r = -0.37, p

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalEuropean Journal of Endocrinology
Issue number1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Endocrinology


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