Abstract
The effect of coronary artery bypass grafting (CABG) on absolute myocardial blood flow (MBF) has not been investigated previously. MBF (ml·min -1·g -1) was measured at rest and during hyperemia (0.56 mg/kg iv dipyridamole) using H 2 15O and positron emission tomography in eight patients with three-vessel disease before surgery and 1 and 6 mo after full revascularization. Baseline MBF was 0.87 ± 0.12 preoperatively and 1.04 ± 0.14 and 0.95 ± 0.13 at 1 and 6 mo after CABG, respectively (P <0.05, 6 mo vs. preoperatively). Hyperemic MBF was 1.36 ± 0.28 preoperatively and increased to 1.98 ± 0.50 and 2.45 ± 0.64 at 1 and 6 mo after CABG, respectively (P <0.01, 6 mo vs. preoperatively). Coronary vasodilator reserve (hyperemic/baseline MBF) increased from 1.59 ± 0.40 preoperatively to 1.93 ± 0.13 and 2.57 ± 0.49 at 1 and 6 mo, respectively (P <0.05, 6 mo vs. preoperatively). Minimal (dipyridamole) coronary resistance (mmHg·min·g -1·ml -1) fell progressively from 59.37 ± 14.56 before surgery to a nadir of 35.76 ± 10.12 at 6 mo after CABG (P <0.01 vs. preoperatively). The results of the present study confirm that CABG improves coronary vasodilator reserve progressively as a result of reduction in minimal coronary resistance. These data suggest persistent microvascular dysfunction that recovers slowly after surgery.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 279 |
| Issue number | 6 48-6 |
| Publication status | Published - 2000 |
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Keywords
- Coronary artery disease
- Coronary microcirculation
- Coronary vasodilator reserve
- Myocardial blood flow
- Positron emission tomography
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Persistent but reversible coronary microvascular dysfunction after bypass grafting. / Spyrou, Nicos; Khan, Masood A.; Rosen, Stuart D.; Foale, Rodney; Davies, D. Wyn; Sogliani, Franco; De Lisle Stanbridge, Rex; Camici, Paolo G.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 279, No. 6 48-6, 2000.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistent but reversible coronary microvascular dysfunction after bypass grafting
AU - Spyrou, Nicos
AU - Khan, Masood A.
AU - Rosen, Stuart D.
AU - Foale, Rodney
AU - Davies, D. Wyn
AU - Sogliani, Franco
AU - De Lisle Stanbridge, Rex
AU - Camici, Paolo G.
PY - 2000
Y1 - 2000
N2 - The effect of coronary artery bypass grafting (CABG) on absolute myocardial blood flow (MBF) has not been investigated previously. MBF (ml·min -1·g -1) was measured at rest and during hyperemia (0.56 mg/kg iv dipyridamole) using H 2 15O and positron emission tomography in eight patients with three-vessel disease before surgery and 1 and 6 mo after full revascularization. Baseline MBF was 0.87 ± 0.12 preoperatively and 1.04 ± 0.14 and 0.95 ± 0.13 at 1 and 6 mo after CABG, respectively (P <0.05, 6 mo vs. preoperatively). Hyperemic MBF was 1.36 ± 0.28 preoperatively and increased to 1.98 ± 0.50 and 2.45 ± 0.64 at 1 and 6 mo after CABG, respectively (P <0.01, 6 mo vs. preoperatively). Coronary vasodilator reserve (hyperemic/baseline MBF) increased from 1.59 ± 0.40 preoperatively to 1.93 ± 0.13 and 2.57 ± 0.49 at 1 and 6 mo, respectively (P <0.05, 6 mo vs. preoperatively). Minimal (dipyridamole) coronary resistance (mmHg·min·g -1·ml -1) fell progressively from 59.37 ± 14.56 before surgery to a nadir of 35.76 ± 10.12 at 6 mo after CABG (P <0.01 vs. preoperatively). The results of the present study confirm that CABG improves coronary vasodilator reserve progressively as a result of reduction in minimal coronary resistance. These data suggest persistent microvascular dysfunction that recovers slowly after surgery.
AB - The effect of coronary artery bypass grafting (CABG) on absolute myocardial blood flow (MBF) has not been investigated previously. MBF (ml·min -1·g -1) was measured at rest and during hyperemia (0.56 mg/kg iv dipyridamole) using H 2 15O and positron emission tomography in eight patients with three-vessel disease before surgery and 1 and 6 mo after full revascularization. Baseline MBF was 0.87 ± 0.12 preoperatively and 1.04 ± 0.14 and 0.95 ± 0.13 at 1 and 6 mo after CABG, respectively (P <0.05, 6 mo vs. preoperatively). Hyperemic MBF was 1.36 ± 0.28 preoperatively and increased to 1.98 ± 0.50 and 2.45 ± 0.64 at 1 and 6 mo after CABG, respectively (P <0.01, 6 mo vs. preoperatively). Coronary vasodilator reserve (hyperemic/baseline MBF) increased from 1.59 ± 0.40 preoperatively to 1.93 ± 0.13 and 2.57 ± 0.49 at 1 and 6 mo, respectively (P <0.05, 6 mo vs. preoperatively). Minimal (dipyridamole) coronary resistance (mmHg·min·g -1·ml -1) fell progressively from 59.37 ± 14.56 before surgery to a nadir of 35.76 ± 10.12 at 6 mo after CABG (P <0.01 vs. preoperatively). The results of the present study confirm that CABG improves coronary vasodilator reserve progressively as a result of reduction in minimal coronary resistance. These data suggest persistent microvascular dysfunction that recovers slowly after surgery.
KW - Coronary artery disease
KW - Coronary microcirculation
KW - Coronary vasodilator reserve
KW - Myocardial blood flow
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0034537421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034537421&partnerID=8YFLogxK
M3 - Article
C2 - 11087215
AN - SCOPUS:0034537421
VL - 279
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 6 48-6
ER -