Persistent global amnesia following right thalamic stroke: An 11-year longitudinal study

Sergio Della Sala, Annalena Venneri, Hans Spinnler

Research output: Contribution to journalArticle

Abstract

The 11-year longitudinal study of a right-handed male patient, L. C., who suffered from a severe amnesic syndrome following a softening in the right thalamus, is reported. Memory impairment involving retrograde and long-term anterograde memory, both verbal and spatial, persisted without modification. Investigation revealed some residual implicit learning ability. Positron emission tomography studies in the resting state displayed a bilateral hypometabolism of the mesial frontal lobes. Evidence suggests that a lesion confined to the thalamus may not on its own account for severe amnesia; that involvement of other structures is necessary for severe amnesia to appear; and that a functional investigation should always be included in cases of small thalamic lesions before drawing conclusions about the structures responsible for a given deficit.

Original languageEnglish
Pages (from-to)90-103
Number of pages14
JournalNeuropsychology
Volume11
Issue number1
DOIs
Publication statusPublished - 1997

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Amnesia
Thalamus
Longitudinal Studies
Stroke
Aptitude
Long-Term Memory
Frontal Lobe
Positron-Emission Tomography
Learning

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology

Cite this

Persistent global amnesia following right thalamic stroke : An 11-year longitudinal study. / Della Sala, Sergio; Venneri, Annalena; Spinnler, Hans.

In: Neuropsychology, Vol. 11, No. 1, 1997, p. 90-103.

Research output: Contribution to journalArticle

Della Sala, Sergio ; Venneri, Annalena ; Spinnler, Hans. / Persistent global amnesia following right thalamic stroke : An 11-year longitudinal study. In: Neuropsychology. 1997 ; Vol. 11, No. 1. pp. 90-103.
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