Persistent high MR signal of the posterior pituitary gland in central diabetes insipidus

Mohamad Maghnie, Eugenio Genovese, Sergio Bernasconi, Silvana Binda, Maurizio Aricò

Research output: Contribution to journalArticlepeer-review


We describe three cases of central diabetes insipidus, each with a different pathogenesis, in which unexpected hyper-intensity of the posterior pituitary gland was seen on T1-weighted MR images obtained at the time of presentation. In the first case (idiopathic), the posterior pituitary signal persisted more than 10 years; in the second case (Langerhans cell histiocytosis), the signal disappeared within 3 months, despite early specific chemotherapy with etoposide; and in the third case (transient), the posterior signal disappeared within 1 year, but it was documented at the time of spontaneous reversal of polyuria and polydipsia.

Original languageEnglish
Pages (from-to)1749-1752
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number9
Publication statusPublished - Oct 1997


  • Diabetes insipidus
  • Histiocytosis
  • Pituitary gland, magnetic resonance

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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