Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?

Maria Antonia De Francesco, Giovanni Ianiro, Marina Monini, Cesare Vezzoli, Richard Fabian Schumacher, Silvia Giliani, Giovanni Lorenzin, Francesca Gurrieri, Arnaldo Caruso

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening.

Original languageEnglish
JournalVaccines
Volume7
Issue number4
DOIs
Publication statusPublished - Nov 16 2019

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