Persistent Müllerian duct syndrome: Lessons learned from managing a series of eight patients over a 10-year period and review of literature regarding malignant risk from the Müllerian remnants

Jasmin Farikullah, Sarah Ehtisham, Simona Nappo, Leena Patel, Supul Hennayake

Research output: Contribution to journalArticle

Abstract

OBJECTIVES • To describe the presentation and management of eight patients with persistent Müllerian duct syndrome (PMDS) seen over a 10-year period at our tertiary centre. • To review the literature of Müllerian malignancies reported in PMDS. PATIENTS AND METHODS • The hospital records of eight patients with PMDS were retrospectively reviewed between 2001 and 2011. • Extensive PubMed searches for PMDS and Müllerian malignancy were performed. RESULTS • Eleven cases with PMDS and malignancy of the Müllerian remnants were identified. • From our own PMDS series: five males presented with bilateral undescended testes and three had unilateral undescended testis. • We found that the Müllerian remnants could be removed by laparoscopy and three patients had simultaneous laparoscopic removal of the Müllerian structures and laparoscopic orchidopexy. CONCLUSIONS • The principle aim of orchidopexy with simultaneous laparoscopic removal of the Müllerian structures can be accomplished with minimal surgical trauma and the benefit of no malignancy risk in the future. • Surgeons should consider excision of the Müllerian remnants where possible.

Original languageEnglish
JournalBJU International
Volume110
Issue number11 C
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Anti-Müllerian hormone
  • Laparoscopy
  • Malignancy
  • Müllerian
  • Persistent Müllerian duct syndrome
  • Undescended testis

ASJC Scopus subject areas

  • Urology

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