Persistent occurrence of serogroup Y/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013

Cecilia Fazio, Arianna Neri, Giovanna Renna, Paola Vacca, Raffaele Antonetti, Anna M aria Barbui, Laura Daprai, Paolo Lanzafame, Lucia Rossi, Iolanda Santino, Carlo Tascini, Caterina Vocale, Paola Stefanelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In Italy, the incidence of invasive meningococcal disease (IMD) has remained stable since 2007 (around 0.3 cases/100,000 inhabitants). However, as reported for other European countries, an increase of serogroup Y Neisseria meningitidis has been observed. In this study we report IMD cases from 2007 to 2013 in Italy and investigate the clinical and epidemiological features of cases affected by serogroup Y. Molecular characteristics of serogroup Y strains are also described. During the study period, the proportion of IMD cases due to serogroup Y increased, ranging from 2% in 2007 to 17% in 2013 (odds ratio (OR): 8.8), whereby the five to 14 years age group was mostly affected (p < 0.001). Overall 81 serogroup Y IMD cases were identified, with a median age of 18 years, ranging from three months to 84 years. Of the 81 respective patient samples, 56 were further subject to molecular typing. The sequence type (ST)-23 complex (clonal complex (cc)23) was predominant among serogroup Y meningococci (54/56 samples), and included nine different STs. Presumably, ST-23 was the founding genotype, with all the other STs presenting as single-locus variants. All cc23 isolates analysed harboured mutations in the lpxL1 gene; however, no associations among lpxL1 mutations, ST and age group were identified. Overall, these findings generate scientific evidence for the use of the quadrivalent meningococcal conjugate vaccine in the five to 14 years age group.

Original languageEnglish
JournalEurosurveillance
Volume20
Issue number45
DOIs
Publication statusPublished - 2015

Fingerprint

Serogroup Y Neisseria meningitidis
Italy
Age Groups
Meningococcal Vaccines
Molecular Typing
Conjugate Vaccines
Mutation
Odds Ratio
Genotype
Serogroup
Incidence
Genes

Keywords

  • meningococcus
  • serogroup Y
  • ST-23 complex

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Persistent occurrence of serogroup Y/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013. / Fazio, Cecilia; Neri, Arianna; Renna, Giovanna; Vacca, Paola; Antonetti, Raffaele; Barbui, Anna M aria; Daprai, Laura; Lanzafame, Paolo; Rossi, Lucia; Santino, Iolanda; Tascini, Carlo; Vocale, Caterina; Stefanelli, Paola.

In: Eurosurveillance, Vol. 20, No. 45, 2015.

Research output: Contribution to journalArticle

Fazio, C, Neri, A, Renna, G, Vacca, P, Antonetti, R, Barbui, AMA, Daprai, L, Lanzafame, P, Rossi, L, Santino, I, Tascini, C, Vocale, C & Stefanelli, P 2015, 'Persistent occurrence of serogroup Y/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013', Eurosurveillance, vol. 20, no. 45. https://doi.org/10.2807/1560-7917.ES.2015.20.45.30061
Fazio, Cecilia ; Neri, Arianna ; Renna, Giovanna ; Vacca, Paola ; Antonetti, Raffaele ; Barbui, Anna M aria ; Daprai, Laura ; Lanzafame, Paolo ; Rossi, Lucia ; Santino, Iolanda ; Tascini, Carlo ; Vocale, Caterina ; Stefanelli, Paola. / Persistent occurrence of serogroup Y/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013. In: Eurosurveillance. 2015 ; Vol. 20, No. 45.
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AU - Neri, Arianna

AU - Renna, Giovanna

AU - Vacca, Paola

AU - Antonetti, Raffaele

AU - Barbui, Anna M aria

AU - Daprai, Laura

AU - Lanzafame, Paolo

AU - Rossi, Lucia

AU - Santino, Iolanda

AU - Tascini, Carlo

AU - Vocale, Caterina

AU - Stefanelli, Paola

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