Abstract
The effects of repeated oCRH (50 μg iv) injections at 2-h intervals on ACTH and cortisol concentrations has been evaluated in normal subjects and in patients with Cushing's disease. In all subjects the first oCRH bolus caused a clear rise in ACTH and cortisol levels; subsequent oCRH injections elicited a similar pattern of hormone release. The ACTH nAUC after each bolus was greater in Cushing's disease. These data indicate that oCRH refractoriness does not occur both in normal conditions and in patients with ACTH-secreting pituitary adenoma.
| Original language | English |
|---|---|
| Pages (from-to) | 471-475 |
| Number of pages | 5 |
| Journal | Neuroendocrinology Letters |
| Volume | 12 |
| Issue number | 6 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
Cite this
Persistent pituitary-adrenal responsiveness to repeated CRH injections in normal subjects and in patients with Cushing's disease. / Ambrosi, B.; Conti, A.; Sartorio, A.; Bochicchio, D.; Grugni, G.; Morabito, F.; Faglia, G.
In: Neuroendocrinology Letters, Vol. 12, No. 6, 1990, p. 471-475.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Persistent pituitary-adrenal responsiveness to repeated CRH injections in normal subjects and in patients with Cushing's disease
AU - Ambrosi, B.
AU - Conti, A.
AU - Sartorio, A.
AU - Bochicchio, D.
AU - Grugni, G.
AU - Morabito, F.
AU - Faglia, G.
PY - 1990
Y1 - 1990
N2 - The effects of repeated oCRH (50 μg iv) injections at 2-h intervals on ACTH and cortisol concentrations has been evaluated in normal subjects and in patients with Cushing's disease. In all subjects the first oCRH bolus caused a clear rise in ACTH and cortisol levels; subsequent oCRH injections elicited a similar pattern of hormone release. The ACTH nAUC after each bolus was greater in Cushing's disease. These data indicate that oCRH refractoriness does not occur both in normal conditions and in patients with ACTH-secreting pituitary adenoma.
AB - The effects of repeated oCRH (50 μg iv) injections at 2-h intervals on ACTH and cortisol concentrations has been evaluated in normal subjects and in patients with Cushing's disease. In all subjects the first oCRH bolus caused a clear rise in ACTH and cortisol levels; subsequent oCRH injections elicited a similar pattern of hormone release. The ACTH nAUC after each bolus was greater in Cushing's disease. These data indicate that oCRH refractoriness does not occur both in normal conditions and in patients with ACTH-secreting pituitary adenoma.
UR - http://www.scopus.com/inward/record.url?scp=0025690090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025690090&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 471
EP - 475
JO - Neuroendocrinology Letters
JF - Neuroendocrinology Letters
SN - 0172-780X
IS - 6
ER -