Persistent pituitary-adrenal responsiveness to repeated CRH injections in normal subjects and in patients with Cushing's disease

B. Ambrosi, A. Conti, A. Sartorio, D. Bochicchio, G. Grugni, F. Morabito, G. Faglia

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of repeated oCRH (50 μg iv) injections at 2-h intervals on ACTH and cortisol concentrations has been evaluated in normal subjects and in patients with Cushing's disease. In all subjects the first oCRH bolus caused a clear rise in ACTH and cortisol levels; subsequent oCRH injections elicited a similar pattern of hormone release. The ACTH nAUC after each bolus was greater in Cushing's disease. These data indicate that oCRH refractoriness does not occur both in normal conditions and in patients with ACTH-secreting pituitary adenoma.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalNeuroendocrinology Letters
Volume12
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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