Persistent pollutants

focus on perfluorinated compounds and kidney

Fiorenza Ferrari, Anita Orlando, Zaccaria Ricci, Claudio Ronco

Research output: Contribution to journalReview article

Abstract

Purpose of review There is increasing interest in the environmental and human damage caused by pollutants. Big efforts are continuously made to monitor their levels and identify safe thresholds. For this purpose, an essential step is to prioritize harmful substances and understand their effect on human body. Perfluorinated compounds (PFCs) deserve particular attention because of their wide diffusion and potential correlation with different diseases including glucose intolerance, hyperlipidaemia, thyroid diseases, gestational diabetes mellitus and hypertension, testicular and genitourinary cancer as well as impaired kidney function. This review focuses on the renal effects of PFCs, with the attempt to clarify their occurrence and pathogenetic mechanisms. Recent findings We reviewed MEDLINE and EMBASE citations between 31 October 2017 and 31 May 2019 and selected human studies measuring PFCs exposure, kidney function markers and the ability of haemodialysis to remove PFCs from the circulating blood. It has been currently clarified that exposure to PFCs is linked with an impaired kidney function and that they can be removed by blood purification. Summary Further studies are required on the potential synergic negative effect of PFCs co-exposure with other pollutants as well as animal studies about the removal capacity of different haemodialysis membranes.

Original languageEnglish
JournalCurrent Opinion in Critical Care
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Kidney
Renal Dialysis
Urogenital Neoplasms
Pregnancy Induced Hypertension
Glucose Intolerance
Gestational Diabetes
Thyroid Diseases
Testicular Neoplasms
Hyperlipidemias
Human Body
MEDLINE
Membranes

Keywords

  • fluorinated compounds
  • kidney function
  • nephrotoxicity
  • persistent pollutants

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Persistent pollutants : focus on perfluorinated compounds and kidney. / Ferrari, Fiorenza; Orlando, Anita; Ricci, Zaccaria; Ronco, Claudio.

In: Current Opinion in Critical Care, 01.01.2019.

Research output: Contribution to journalReview article

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